Increased brain connectivity and activation after cognitive rehabilitation in Parkinson's disease: a randomized controlled trial.
Increased brain connectivity and activation after cognitive rehabilitation in Parkinson's disease: a randomized controlled trial.
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DOI：
10.1007/s11682-016-9639-x
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发表时间：
2017-12
影响因子：
3.2
通讯作者：
Ibarretxe-Bilbao N
中科院分区：
文献类型：
--
作者：
Díez-Cirarda M;Ojeda N;Peña J;Cabrera-Zubizarreta A;Lucas-Jiménez O;Gómez-Esteban JC;Gómez-Beldarrain MÁ;Ibarretxe-Bilbao N
认知康复计划已被证明在改善帕金森病（PD）的认知功能的疗效，但很少有人知道与帕金森病的综合认知康复的大脑变化。评估帕金森病患者参加三个月的综合认知康复计划（REHACOP）后大脑结构和功能的变化。将44例PD患者随机分为REHACOP组（认知康复）和对照组（作业治疗）。T1加权，弥散加权和功能性磁共振成像（fMRI）在休息状态和记忆范式（学习和识别任务），在治疗前和治疗后获得。采用重复测量ANOVA 2 × 2评估组x时间相互作用的大脑变化。在静息态fMRI中，与对照组相比，REHACOP组显示左下颞叶和双侧背外侧前额叶皮质之间的大脑连接显著增加。此外，在识别功能磁共振成像任务，REHACOP组显示出显着增加的大脑激活在左中颞区相比，对照组。在学习功能磁共振成像任务中，REHACOP组在治疗后与治疗前相比，左下额叶的大脑激活增加。治疗前后无明显结构变化。最后，REHACOP组在治疗后的大脑连接和激活与认知表现之间表现出显著的正相关。这项随机对照试验表明，综合性认知康复计划可以在PD患者中产生显着的脑功能变化，并为认知康复计划在PD治疗方法中的疗效提供了证据。
Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson’s disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a three-month integrative cognitive rehabilitation program (REHACOP). Forty-four PD patients were randomly divided into REHACOP group (cognitive rehabilitation) and a control group (occupational therapy). T1-weighted, diffusion weighted and functional magnetic resonance images (fMRI) during resting-state and during a memory paradigm (with learning and recognition tasks) were acquired at pre-treatment and post-treatment. Cerebral changes were assessed with repeated measures ANOVA 2 × 2 for group x time interaction. During resting-state fMRI, the REHACOP group showed significantly increased brain connectivity between the left inferior temporal lobe and the bilateral dorsolateral prefrontal cortex compared to the control group. Moreover, during the recognition fMRI task, the REHACOP group showed significantly increased brain activation in the left middle temporal area compared to the control group. During the learning fMRI task, the REHACOP group showed increased brain activation in the left inferior frontal lobe at post-treatment compared to pre-treatment. No significant structural changes were found between pre- and post-treatment. Finally, the REHACOP group showed significant and positive correlations between the brain connectivity and activation and the cognitive performance at post-treatment. This randomized controlled trial suggests that an integrative cognitive rehabilitation program can produce significant functional cerebral changes in PD patients and adds evidence to the efficacy of cognitive rehabilitation programs in the therapeutic approach for PD.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
4.4
作者：
Ibarretxe-Bilbao, Naroa;Junque, Carme;Tolosa, Eduardo
通讯作者：
Tolosa, Eduardo
影响因子：
14.5
作者：
Belleville, Sylvie;Clement, Francis;Gauthier, Serge
通讯作者：
Gauthier, Serge
影响因子：
3.7
作者：
Biundo R;Calabrese M;Weis L;Facchini S;Ricchieri G;Gallo P;Antonini A
通讯作者：
Antonini A
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI