Projections from the five divisions of the orbital cortex to the thalamus in the rat.

Projections from the five divisions of the orbital cortex to the thalamus in the rat.
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从大鼠眼眶皮层的五个部分到丘脑的投影。

DOI:
10.1002/cne.25419
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发表时间:
2023
期刊:
The Journal of comparative neurology
影响因子:
--
通讯作者:
Linley,StephanieB
Linley,StephanieB
中科院分区:
--
文献类型:
--
作者:
Vertes,RobertP;Hoover,WalterB;Witter,MennoP;Yanik,MehmetFatih;Rojas,AmandaKP;Linley,StephanieB

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相似文献

大鼠的眶皮质(ORB)由五个部分组成:内侧(MO)、腹侧(VO)、腹外侧(VLO)、外侧(LO)和背外侧(DLO)眶皮质。之前没有任何报告全面检查和比较 ORB 各部分到丘脑的投影。使用顺行解剖示踪剂菜豆白细胞凝集素,我们描述了大鼠从 ORB 的五个部分到丘脑的传出投射。我们证明,在一些重叠的情况下,ORB 的每个部分都以不同(且独特)的方式分布到丘脑的细胞核。总体而言,ORB投射到丘脑中数量相对有限的位点,并且完全分布到内侧/中线丘脑的结构,同时完全避开丘脑的外侧区域或主核。丘脑的主要终止位点是中线丘脑的丘脑旁核(PT)和团聚核(RE),内侧核(MDm)和中央核(MDc),中间背核,头侧层内复合体的中央外侧核,旁中央核和中央内侧核以及内侧核(SM)。除一些例外,ORB 的内侧分裂(MO、VO)主要针对“边缘相关”核团,如 PT、RE 和 MDm,而外侧分裂(VLO、LO、DLO)主要分布于“感觉运动相关”核团,包括 MDc、SM 和头侧层内复合体。如本文所讨论的,内侧/中线丘脑可以代表眼眶皮层和海马体之间以及ORB和内侧前额叶皮层之间的重要链接(或桥梁)。总之,目前的结果表明,眼眶皮层的每个部分以不同的方式投射到丘脑的核团,这表明眼眶皮层的每个部分都有独特的功能。
The orbital cortex (ORB) of the rat consists of five divisions: the medial (MO), ventral (VO), ventrolateral (VLO), lateral (LO), and dorsolateral (DLO) orbital cortices. No previous report has comprehensively examined and compared projections from each division of the ORB to the thalamus. Using the anterograde anatomical tracer,Phaseolus vulgarisleucoagglutinin, we describe the efferent projections from the five divisions of the ORB to the thalamus in the rat. We demonstrated that, with some overlap, each division of the ORB distributed in a distinct (and unique) manner to nuclei of the thalamus. Overall, ORB projected to a relatively restricted number of sites in the thalamus, and strikingly distributed entirely to structures of the medial/midline thalamus, while completely avoiding lateral regions or principal nuclei of the thalamus. The main termination sites in the thalamus were the paratenial nucleus (PT) and nucleus reuniens (RE) of the midline thalamus, the medial (MDm) and central (MDc) divisions of the mediodorsal nucleus, the intermediodorsal nucleus, the central lateral, paracentral, and central medial nuclei of the rostral intralaminar complex and the submedial nucleus (SM). With some exceptions, medial divisions of the ORB (MO, VO) mainly targeted “limbic‐associated” nuclei such as PT, RE, and MDm, whereas lateral division (VLO, LO, DLO) primarily distributed to “sensorimotor‐associated” nuclei including MDc, SM, and the rostral intralaminar complex. As discussed herein, the medial/midline thalamus may represent an important link (or bridge) between the orbital cortex and the hippocampus and between the ORB and medial prefrontal cortex. In summary, the present results demonstrate that each division of the orbital cortex projects in a distinct manner to nuclei of the thalamus which suggests unique functions for each division of the orbital cortex.
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DOI: --
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