Retrosplenial cortex codes for permanent landmarks.
Retrosplenial cortex codes for permanent landmarks.
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DOI：
10.1371/journal.pone.0043620
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Maguire EA
中科院分区：
文献类型：
--
作者：
Auger SD;Mullally SL;Maguire EA
地标是我们对环境的内部表征的关键组成部分，但它们的具体属性很少被研究，而且对它们在大脑中的处理方式知之甚少。在这里，我们描述了一个大的地标沿着的一系列功能，包括大小，视觉显着性，导航实用性，和持久性。当人类参与者在功能性磁共振成像（fMRI）过程中查看这些单个地标的图像时，海马旁皮质（PHC）和压后皮质（RSC）都被地标特征所吸引，但方式不同。PHC对一系列地标属性作出反应，而RSC仅对最永久的地标作出反应。此外，当参与者被分为好和差的导航员，后者在识别最永久的地标方面的可靠性明显降低，并且在查看这些地标时，RSC和前背侧丘脑的反应降低。RSC在导航方面有着广泛的牵连，但其确切的作用仍然不确定。我们的研究结果表明，RSC的主要功能可能是处理环境中最稳定的功能，这可能是成功导航的先决条件。
Landmarks are critical components of our internal representation of the environment, yet their specific properties are rarely studied, and little is known about how they are processed in the brain. Here we characterised a large set of landmarks along a range of features that included size, visual salience, navigational utility, and permanence. When human participants viewed images of these single landmarks during functional magnetic resonance imaging (fMRI), parahippocampal cortex (PHC) and retrosplenial cortex (RSC) were both engaged by landmark features, but in different ways. PHC responded to a range of landmark attributes, while RSC was engaged by only the most permanent landmarks. Furthermore, when participants were divided into good and poor navigators, the latter were significantly less reliable at identifying the most permanent landmarks, and had reduced responses in RSC and anterodorsal thalamus when viewing such landmarks. The RSC has been widely implicated in navigation but its precise role remains uncertain. Our findings suggest that a primary function of the RSC may be to process the most stable features in an environment, and this could be a prerequisite for successful navigation.
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影响因子：
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