Contrasting prevalence of delta hepatitis markers in parenteral drug abusers with and without AIDS.
Contrasting prevalence of delta hepatitis markers in parenteral drug abusers with and without AIDS.
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患有和未患有艾滋病的肠外吸毒者中丁型肝炎标志物的流行率对比。
DOI：
10.1093/infdis/162.2.538
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Raghunath,J
中科院分区：
文献类型：
--
作者：
Kreek,MJ;DesJarlais,DC;Trepo,CL;Novick,DM;Abdul-Quader,A;Raghunath,J
Parenteral drug abusers are the second largest group at risk for developing AIDS (25% of US cases) and a major risk group for infection with both hepatitis B virus (HBV) and the HBVdependent RNA hepatitis delta virus (HDV). This study was conducted to determine the prevalence in 1984–1985 and relationships of HDV and HBV infections in 372 unselected parenteral drug abusers without AIDS or symptoms related to human immunodeficiency virus type 1 (HIV-1) infection (but 49% ofwhom were positive for HIV-l antibodies) and in 53 drug abusers hospitalized with AIDS. The prevalence ofHDV markers in the combined study groups was 20%; 81% of study subjects with hepatitis B surface antigenemia (HBsAg) had one marker for HDV infection. Significant differences were found between patients with and without AIDS with respect to the prevalence of hepatitis delta antigen (5.7% vs. 0.8%,P< .05) and antibody (0 vs. 21.4%,P< .01) and HBsAg (15.1% vs. 5.1%,P< .05). The significantly higher prevalence of hepatitis delta antigen and HBsAg in subjects with AIDS suggests that persistence or reactivation ofthese viruses is significantly greater among parenteral drug abusers with AIDS than among those without AIDS. These findings, along with the absence of hepatitis delta antibodies in the drug abusers with AIDS, are probably related to the profound general immunosuppression that occurs in AIDS.
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肿瘤科的乙型肝炎。
影响因子：
158.5
作者：
J. Wands;J. Walker;T. Davis;L. Waterbury;A. Owens;C. C. Carpenter
通讯作者：
C. C. Carpenter
DOI：
10.1001/jama.1989.03420070058030
发表时间：
1989-02
期刊：
JAMA
影响因子：
--
作者：
D. C. Jarlais;S. R. Friedman;D. Novick;J. L. Sotheran;Pauline A. Thomas;S. Yancovitz;D. Mildvan;J. M. Weber;M. Kreek;R. Maslansky;Sarah Bartelme;T. Spira;M. Marmor
通讯作者：
D. C. Jarlais;S. R. Friedman;D. Novick;J. L. Sotheran;Pauline A. Thomas;S. Yancovitz;D. Mildvan;J. M. Weber;M. Kreek;R. Maslansky;Sarah Bartelme;T. Spira;M. Marmor
人类免疫缺陷病毒可能重新激活丁型肝炎并伴有慢性δ抗原血症。
影响因子：
--
作者：
A. Shattock;H. Finlay;I. Hillary
通讯作者：
I. Hillary
患有慢性肝病的 HBsAg 阳性和 HBsAg 阴性物质滥用者的丁型肝炎病毒抗体
影响因子：
12.7
作者：
D. Novick;P. Farci;P. Karayiannis;A. Gelb;R. Stenger;M. Kreek;H. Thomas
通讯作者：
H. Thomas
影响因子：
6.4
作者：
NOVICK, DM;FARCI, P;KREEK, MJ
通讯作者：
KREEK, MJ