Activation of Latent Courtship Circuitry in the Brain of Drosophila Females Induces Male-like Behaviors.
Activation of Latent Courtship Circuitry in the Brain of Drosophila Females Induces Male-like Behaviors.
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DOI：
10.1016/j.cub.2016.07.021
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发表时间：
2016-09-26
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影响因子：
--
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中科院分区：
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果蝇的求偶行为为研究先天性二态性行为提供了一个强大的实验范式。雄性果蝇向潜在的配偶展示出精心设计的求偶表演。雌性从不主动向雄性求爱，但它们对雄性表现的反应决定了交配是否会真正发生。性别特异性行为通过性别决定基因 doublesex (dsx) 和 Fruitless (fru) 的作用而根植于神经系统。大脑中雄性特有的 dsx/fru+ P1 神经元的激活会引发雄性的求爱表现，这表明雄性特有的神经元触发了这种性别特异性的行为。在雌性中，dsx+ 神经元在性接受和交配后行为中发挥着关键作用。然而，目前尚不清楚这些回路中的 dsx+ 神经元和二态性如何导致雄性和雌性表现出不同的行为。在这里，我们操纵女性大脑中 dsx+ 神经元的功能，以研究驱动女性行为的高阶神经元。令人惊讶的是，我们发现雌性大脑中 dsx+ 神经元的激活会通过促进雄性典型的求偶行为来诱导雌性表现得像雄性。激活的雌性会向同种雄性或雌性以及其他果蝇物种表现出求爱行为。我们发现了对驱动雄性求爱至关重要的特定 dsx+ 神经元，并确定了在激活的雌性中触发此类行为的信息素。虽然雄性求偶行为被认为是由雄性特有的中枢神经元产生的，但我们的研究表明，雌性大脑配备有潜在的求偶电路，能够诱导这种雄性特有的行为程序。大脑 dsx-pC1 神经元的激活促进雌性的雄性求爱 激活的雌性向同种雄性和雌性以及其他果蝇物种求爱 甲基信息素触发激活的雌性中的雄性求爱行为 雌性大脑配备了潜在的类似雄性行为的电路 Rezával 等人。发现大脑中特定神经元的激活会诱导雌性果蝇表现出类似雄性的求爱行为，并确定了诱导这种行为的信息素。因此，这项研究表明，雌性果蝇大脑配备了潜在的求爱电路，能够诱导雄性特有的行为程序。
Courtship in Drosophila melanogaster offers a powerful experimental paradigm for the study of innate sexually dimorphic behaviors. Fruit fly males exhibit an elaborate courtship display toward a potential mate. Females never actively court males, but their response to the male’s display determines whether mating will actually occur. Sex-specific behaviors are hardwired into the nervous system via the actions of the sex determination genes doublesex (dsx) and fruitless (fru). Activation of male-specific dsx/fru+ P1 neurons in the brain initiates the male’s courtship display, suggesting that neurons unique to males trigger this sex-specific behavior. In females, dsx+ neurons play a pivotal role in sexual receptivity and post-mating behaviors. Yet it is still unclear how dsx+ neurons and dimorphisms in these circuits give rise to the different behaviors displayed by males and females. Here, we manipulated the function of dsx+ neurons in the female brain to investigate higher-order neurons that drive female behaviors. Surprisingly, we found that activation of female dsx+ neurons in the brain induces females to behave like males by promoting male-typical courtship behaviors. Activated females display courtship toward conspecific males or females, as well other Drosophila species. We uncovered specific dsx+ neurons critical for driving male courtship and identified pheromones that trigger such behaviors in activated females. While male courtship behavior was thought to arise from male-specific central neurons, our study shows that the female brain is equipped with latent courtship circuitry capable of inducing this male-specific behavioral program. Activation of brain dsx-pC1 neurons promote male-like courtship in females Activated females court conspecific males and females and other Drosophila species Methyl pheromones trigger male courtship behaviors in activated females The female brain is equipped with latent circuitry underlying male-like behavior Rezával et al. found that activation of specific neurons in the brain induces female fruit flies to display male-like courtship behaviors and identified pheromones that induce such behaviors. Thus, this study shows that the female fly brain is equipped with latent courtship circuitry that is capable of inducing a male-specific behavioral program.
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影响因子：
9.2
作者：
Rezaval, Carolina;Pavlou, Hania J.;Dornan, Anthony J.;Chan, Yick-Bun;Kravitz, Edward A.;Goodwin, Stephen F.
通讯作者：
Goodwin, Stephen F.
影响因子：
64.5
作者：
Asahina K;Watanabe K;Duistermars BJ;Hoopfer E;González CR;Eyjólfsdóttir EA;Perona P;Anderson DJ
通讯作者：
Anderson DJ
影响因子：
5.7
作者：
Kohl J;Huoviala P;Jefferis GS
通讯作者：
Jefferis GS
DOI：
10.1016/j.cub.2013.12.051
发表时间：
2014-03-31
期刊：
Current biology : CB
影响因子：
--
作者：
Rezával C;Nojima T;Neville MC;Lin AC;Goodwin SF
通讯作者：
Goodwin SF
影响因子：
64.8
作者：
Billeter, Jean-Christophe;Atallah, Jade;Levine, Joel D.
通讯作者：
Levine, Joel D.