Sexually dimorphic octopaminergic neurons modulate female postmating behaviors in Drosophila.
Sexually dimorphic octopaminergic neurons modulate female postmating behaviors in Drosophila.
复制标题
DOI：
10.1016/j.cub.2013.12.051
复制
发表时间：
2014-03-31
期刊：
影响因子：
--
通讯作者：
Goodwin SF
中科院分区：
文献类型：
--
作者：
Rezával C;Nojima T;Neville MC;Lin AC;Goodwin SF
交配会引起许多物种深刻的行为和生理变化，这对于繁殖成功至关重要。交配后，雌性果蝇会降低性接受能力并增加产卵量。交配期间雄性性肽（SP）的转移通过子宫中的 SP 感觉神经元介导这些交配后反应，该反应由本体感觉神经元标记扒手（ppk）和性别决定基因 doublesex（dsx）和无果（fru）的共表达定义。尽管表达 SP 信号下游 dsx 的神经元已被证明可以调节交配后行为，但雌性神经系统如何协调从交配前状态到交配后状态的变化尚不清楚。在这里，我们展示了神经调节剂章鱼胺 (OA) 在雌性交配后反应中的作用。 OA 的缺乏会扰乱已交配雌性的交配后反应，而 OA 的增加会诱导未交配雌性的交配后反应。使用新型 dsxFLP 等位基因，我们发现了与参与交配后反应调节的 OA 信号传导相关的 dsx 神经元元件。我们在腹部神经节中发现了一小部分性别二态性 OA/dsx+ 神经元（女性中大约有 9 个细胞）。我们的结果与交配后 OA 神经元信号增加的模型一致，这反过来又调节雌性行为和生理学的变化以响应生殖状态。
Mating elicits profound behavioral and physiological changes in many species that are crucial for reproductive success. After copulation, Drosophila melanogaster females reduce their sexual receptivity and increase egg laying. Transfer of male sex peptide (SP) during copulation mediates these postmating responses via SP sensory neurons in the uterus defined by coexpression of the proprioceptive neuronal marker pickpocket (ppk) and the sex-determination genes doublesex (dsx) and fruitless (fru). Although neurons expressing dsx downstream of SP signalling have been shown to regulate postmating behaviors, how the female nervous system coordinates the change from pre- to postcopulatory states is unknown. Here, we show a role of the neuromodulator octopamine (OA) in the female postmating response. Lack of OA disrupts postmating responses in mated females, while increase of OA induces postmating responses in virgin females. Using a novel dsxFLP allele, we uncovered dsx neuronal elements associated with OA signaling involved in modulation of postmating responses. We identified a small subset of sexually dimorphic OA/dsx+ neurons (approximately nine cells in females) in the abdominal ganglion. Our results are consistent with a model whereby OA neuronal signaling increases after copulation, which in turn modulates changes in female behavior and physiology in response to reproductive state.
登录
查看更多内容
影响因子：
9.2
作者：
Rezaval, Carolina;Pavlou, Hania J.;Dornan, Anthony J.;Chan, Yick-Bun;Kravitz, Edward A.;Goodwin, Stephen F.
通讯作者：
Goodwin, Stephen F.
DOI：
10.1073/pnas.1631700100
发表时间：
2003-08-19
影响因子：
11.1
作者：
Liu, HF;Kubli, E
通讯作者：
Kubli, E
影响因子：
2.7
作者：
Monastirioti, M
通讯作者：
Monastirioti, M
DOI：
10.1073/pnas.1220018110
发表时间：
2013-10-22
影响因子：
11.1
作者：
Rubinstein, C. Dustin;Wolfner, Mariana F.
通讯作者：
Wolfner, Mariana F.
影响因子：
2.2
作者：
Barnes, Andrew I.;Boone, James M.;Chapman, Tracey
通讯作者：
Chapman, Tracey