Toxicological evaluation of realistic emission source aerosols (TERESA)--power plant studies: assessment of breathing pattern.
Toxicological evaluation of realistic emission source aerosols (TERESA)--power plant studies: assessment of breathing pattern.
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DOI：
10.3109/08958378.2010.578169
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发表时间：
2011-08
影响因子：
2.1
通讯作者：
Godleski JJ
中科院分区：
文献类型：
--
作者：
Diaz EA;Lemos M;Coull B;Long MS;Rohr AC;Ruiz P;Gupta T;Kang CM;Godleski JJ
我们研究多污染物气溶胶的方法隔离了一个单一的排放源，评估了来自该源的初级和次级颗粒的毒性，并模拟了排放后在大气中发生的化学反应。美国三个燃煤电厂使用不同的煤和不同的排放控制进行了评估。在某些实验中加入了由α-蒎烯和/或氨衍生的二次有机气溶胶（SOA）。雄性Sprague-Dawley大鼠暴露于过滤空气或不同的大气混合物6小时。在每个工厂研究的情景包括：初级粒子（P）;次级（氧化）粒子（PO）;氧化粒子+ SOA（POS）;氧化和中和粒子+ SOA（脑桥）;还研究了其他控制情景。使用全身体积描记室在暴露期间获得连续呼吸数据。在评估的12种呼吸结果中，每种结果在某些工厂和4种情景中的某些情况下都有统计学显著变化。暴露于PO情景（呼吸频率增加，吸气和呼气时间减少）和脑桥情景（呼气峰流量和呼气流量减少50%）时发现最稳健的结局。在单变量分析中，脑桥结果与铵、中和硫酸盐和元素碳（EC）最密切相关，但在多变量分析中仅与EC相关。对照方案O（无初级颗粒的氧化）与PO的变化相似。调整后的R2分析表明，情景是一个更好的预测呼吸反应比单个组件，这表明，复杂的大气混合物是负责呼吸的影响。
Our approach to study multi-pollutant aerosols isolates a single emissions source, evaluates the toxicity of primary and secondary particles derived from this source, and simulates chemical reactions that occur in the atmosphere after emission. Three U.S. coal-fired power plants utilizing different coals and with different emission controls were evaluated. Secondary organic aerosol (SOA) derived from α-pinene and/or ammonia was added in some experiments. Male Sprague-Dawley rats were exposed for 6 h to filtered air or different atmospheric mixtures. Scenarios studied at each plant included the following: primary particles (P); secondary (oxidized) particles (PO); oxidized particles + SOA (POS); and oxidized and neutralized particles + SOA (PONS); additional control scenarios were also studied. Continuous respiratory data were obtained during exposures using whole body plethysmography chambers. Of the 12 respiratory outcomes assessed, each had statistically significant changes at some plant and with some of the 4 scenarios. The most robust outcomes were found with exposure to the PO scenario (increased respiratory frequency with decreases in inspiratory and expiratory time); and the PONS scenario (decreased peak expiratory flow and expiratory flow at 50%). PONS findings were most strongly associated with ammonium, neutralized sulfate, and elemental carbon (EC) in univariate analyses, but only with EC in multivariate analyses. Control scenario O (oxidized without primary particles) had similar changes to PO. Adjusted R2 analyses showed that scenario was a better predictor of respiratory responses than individual components, suggesting that the complex atmospheric mixture was responsible for respiratory effects.
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影响因子：
3.3
作者：
Lundblad, LKA;Irvin, CG;Bates, JHT
通讯作者：
Bates, JHT
影响因子：
8.3
作者：
DOCKERY, DW;SCHWARTZ, J;SPENGLER, JD
通讯作者：
SPENGLER, JD
影响因子：
3.3
作者：
Glaab, T;Hoymann, HG;Fabel, H
通讯作者：
Fabel, H
影响因子：
--
作者：
Lomask, Morton
通讯作者：
Lomask, Morton
影响因子：
2.1
作者：
Coull BA;Wellenius GA;Gonzalez-Flecha B;Diaz E;Koutrakis P;Godleski JJ
通讯作者：
Godleski JJ