Subthreshold depressive symptoms relate to cuneus structure: Thickness asymmetry and sex differences.
Subthreshold depressive symptoms relate to cuneus structure: Thickness asymmetry and sex differences.
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DOI：
10.1016/j.jpsychires.2021.12.013
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发表时间：
2021-12-12
影响因子：
4.8
通讯作者：
Minto LR
中科院分区：
文献类型：
--
作者：
Dotson VM;Bogoian HR;Gradone AM;Taiwo Z;Minto LR
尽管额边缘区域在抑郁症研究中占据重要地位，但最近的研究也涉及后脑区域，包括楔叶。目前的研究调查了 18 岁至 81 岁健康成年人的抑郁症状与楔骨皮质厚度不对称之间的关系，其中抑郁症状主要处于阈值以下水平。计算楔叶皮质厚度的不对称指数[(左−右)×100/(左+右)]，并利用流行病学研究中心抑郁量表的总分进行回归分析，预测该不对称指数，控制年龄和性别。较高的抑郁症状与楔骨皮质厚度的左>右不对称相关，反映出左半球的皮质厚度比右半球更大。 CES-D 分量表的后续分析显示，对抑郁症的躯体症状有显着影响，但对负面情绪或快感缺乏没有影响。按性别分层的分析对男性产生了显着影响，但对女性没有产生显着影响。这项初步研究的结果进一步支持了楔叶在抑郁症中的作用，并强调了检查抑郁症神经生物学中症状维度和性别差异的重要性。
Despite the prominence of frontolimbic regions in depression research, recent studies also implicate posterior brain regions, including the cuneus. The current study examined the relationship between depressive symptoms and asymmetry in cuneal cortical thickness in healthy adults between the ages of 18 and 81 with primarily subthreshold levels of depressive symptoms. An asymmetry index was calculated for cortical thickness in the cuneus [(left −right) × 100 / (left + right)], and regression analyses were conducted with total scores on the Center for Epidemiologic Studies Depression Scale predicting this asymmetry index, controlling for age and sex. Higher depressive symptoms were associated with a left > right asymmetry in cuneal cortical thickness, reflecting greater cortical thickness in the left hemisphere compared to right hemisphere. Follow-up analyses examining CES-D subscales showed significant effects for somatic symptoms of depression, but not negative affect or anhedonia. Analyses stratified by sex yielded significant effects in men but not in women. Results of this preliminary study further support the cuneus’ role in depression and highlight the importance of examining symptom dimensions and sex differences in the neurobiology of depression.
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