Combining gray matter volume in the cuneus and the cuneus-prefrontal connectivity may predict early relapse in abstinent alcohol-dependent patients.
Combining gray matter volume in the cuneus and the cuneus-prefrontal connectivity may predict early relapse in abstinent alcohol-dependent patients.
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结合楔叶灰质体积和楔叶-前额叶连接可以预测戒酒酒精依赖患者的早期复发
DOI：
10.1371/journal.pone.0196860
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Cui C
中科院分区：
文献类型：
--
作者：
Wang J;Fan Y;Dong Y;Ma M;Dong Y;Niu Y;Jiang Y;Wang H;Wang Z;Wu L;Sun H;Cui C
制定更有效的策略来防止复发仍然是治疗物质依赖的主要挑战之一。先前的研究已经发现了戒酒者的大脑异常。然而，这些在戒酒过程中持续存在的脑缺陷是否可以预测酒精使用的早期复发还没有得到很好的证实。本研究旨在通过调查戒酒酒精依赖患者持续的大脑异常来确定复发易感性的生物标志物。研究收集了56名戒酒的酒精依赖男性住院患者和33名年龄匹配的健康男性对照者的脑成像和冲动行为数据。采用体素形态测量法观察两组脑灰质体积差异。静息状态功能连通性使用脑灰质缺陷区域作为种子区进行检查。初步前瞻性研究设计将患者分为平均禁欲期为62天的戒酒者和复吸者。与健康对照相比，复发者和戒酒者都表现出楔叶灰质体积显著减少。功能连通性分析显示，相对于戒酒者，复吸者在涉及执行控制和显著性的大脑区域网络中表现出以楔形为中心的负功能连通性增加。在3个月的随访期间，左侧楔叶灰质体积异常以及右侧楔叶与双侧背外侧前额叶皮质之间的功能连通性可以成功预测复发。研究结果表明，楔叶灰质体积异常和静息状态楔叶-前额叶功能连通性可能在酗酒者治疗结果不佳中起重要作用，并可作为复发易感的有用神经标志物。
Developing more effective strategies to prevent relapse remains one of the major challenges of treating substance dependence. Previous studies have identified brain abnormalities in abstinent alcoholics. However, whether these persistent brain deficits in abstinence could predict early relapse to alcohol use has not been well established. This study aimed to identify biomarkers of relapse vulnerability by investigating persistent brain abnormalities in abstinent alcohol-dependent patients. Brain imaging and impulsive behavior data were collected from 56 abstinent alcohol-dependent male inpatients and 33 age-matched male healthy controls. Voxel-based morphometry was used to investigate the differences of grey matter volume between the groups. The resting-state functional connectivity was examined using brain areas with gray matter deficits as seed regions. A preliminary prospective study design was used to classify patients into abstainers and relapsers after a 62-day average abstinence period. Compared with healthy controls, both relapsers and abstainers exhibited significantly reduced gray matter volume in the cuneus. Functional connectivity analysis revealed that relapsers relative to abstainers demonstrated increased cuneus-centered negative functional connectivity within a network of brain regions which are involved in executive control and salience. Abnormal gray matter volume in the left cuneus and the functional connectivity between the right cuneus and bilateral dorsolateral prefrontal cortex could successfully predict relapse during the 3-month follow-up period. Findings suggest that the abnormal gray matter volume in the cuneus and resting-state cuneus-prefrontal functional connectivity may play an important role in poor treatment outcomes in alcoholics and serve as useful neural markers of relapse vulnerability.
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影响因子：
--
作者：
Hong, L. Elliot;Gu, Hong;Yang, Yihong;Ross, Thomas J.;Salmeron, Betty Jo;Buchholz, Brittany;Thaker, Gunvant K.;Stein, Elliot A.
通讯作者：
Stein, Elliot A.
影响因子：
3
作者：
Khullar S;Michael AM;Cahill ND;Kiehl KA;Pearlson G;Baum SA;Calhoun VD
通讯作者：
Calhoun VD
基于2020年中国成年人多中心MRI数据集的脑图谱构建
影响因子：
4.6
作者：
Liang, Peipeng;Shi, Lin;Li, Kuncheng
通讯作者：
Li, Kuncheng
DOI：
10.1073/pnas.0901831106
发表时间：
2009-06-23
影响因子：
11.1
作者：
Deco, Gustavo;Jirsa, Viktor;Koetter, Rolf
通讯作者：
Koetter, Rolf
影响因子：
3.4
作者：
Loeber, Sabine;Vollstaedt-Klein, Sabine;Kiefer, Falk
通讯作者：
Kiefer, Falk