Cerebellar direct current stimulation enhances motor learning in older adults.
Cerebellar direct current stimulation enhances motor learning in older adults.
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DOI：
10.1016/j.neurobiolaging.2014.03.030
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发表时间：
2014-10
影响因子：
4.2
通讯作者：
Celnik PA
中科院分区：
文献类型：
--
作者：
Hardwick RM;Celnik PA
开发新的方法来对抗与年龄相关的运动功能下降是维持老年人健康和功能的关键，老年人是一个快速增长的人口亚群。运动适应是运动学习的一种形式，与年轻人相比，健康的老年人的运动适应能力受到了损害。在这里，我们测试了小脑的兴奋性阳极经颅直流电刺激（tDCS）是否可以增强老年受试者的适应性。参与者完成了一项“向中心”伸手的任务，以适应突然引入的视觉光标旋转。接受假tDCS的老年参与者（平均年龄56.3±6.8岁）比接受假tDCS的年轻参与者（平均年龄20.7±2.1岁）适应速度慢。相比之下，接受无节点tDCS的老年参与者（平均年龄59.6±8.1岁）适应更快，其速度与年轻受试者相似。我们得出结论，小脑淋巴结tDCS增强了老年人的运动适应。我们的研究结果强调了使用小脑tDCS来对抗与年龄相关的运动学习缺陷的新方法的有效性。
Developing novel approaches to combat age related declines in motor function is key to maintaining health and function in older adults, a subgroup of the population that is rapidly growing. Motor adaptation, a form of motor learning, has been shown to be impaired in healthy older subjects compared to their younger counterparts. Here we tested whether excitatory anodal transcranial direct current stimulation (tDCS) over the cerebellum could enhance adaptation in older subjects. Participants performed a ‘center-out’ reaching task, adapting to the sudden introduction of a visual cursor rotation. Older participants receiving sham tDCS (mean age 56.3 ± 6.8 years) were slower to adapt than younger participants (mean age 20.7 ± 2.1 years. In contrast, older participants who received anodal tDCS (mean age 59.6 ± 8.1 years) adapted faster, with a rate that was similar to younger subjects. We conclude that cerebellar anodal tDCS enhances motor adaptation in older individuals. Our results highlight the efficacy of the novel approach of using cerebellar tDCS to combat age related deficits in motor learning.
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DOI：
10.1523/jneurosci.2184-09.2009
发表时间：
2009-07-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Galea JM;Jayaram G;Ajagbe L;Celnik P
通讯作者：
Celnik P
影响因子：
3.8
作者：
Seidler, Rachael D.
通讯作者：
Seidler, Rachael D.
影响因子：
4.2
作者：
Hummel, Friedhelm C.;Heise, Kirstin;Cohen, Leonardo G.
通讯作者：
Cohen, Leonardo G.
影响因子：
2.6
作者：
Kuo, Min-Fang;Unger, Mandy;Nitsche, Michael A.
通讯作者：
Nitsche, Michael A.
影响因子：
2.9
作者：
Bernard JA;Seidler RD
通讯作者：
Seidler RD