Modafinil and memory: effects of modafinil on Morris water maze learning and Pavlovian fear conditioning.
Modafinil and memory: effects of modafinil on Morris water maze learning and Pavlovian fear conditioning.
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DOI：
10.1037/a0014366
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发表时间：
2009-04
影响因子：
1.9
通讯作者：
Anagnostaras, Stephan G.
中科院分区：
文献类型：
--
作者：
Shuman, Tristan;Wood, Suzanne C.;Anagnostaras, Stephan G.
莫达非尼已被证明可以促进清醒，一些研究表明该药物可以改善认知功能。由于许多相似之处，其作用机制可能与经典精神兴奋剂相当，尽管莫达非尼在清醒和认知增强方面作用的确切机制尚不清楚。目前的研究旨在进一步研究莫达非尼作为认知增强剂对小鼠海马依赖性记忆的影响。训练前给予高剂量莫达非尼（75 mg/kg，腹腔注射）可改善莫里斯水迷宫的采集。仅在测试前服用时，莫达非尼不会影响水迷宫的表现。我们还检查了莫达非尼（0.075 – 75 mg/kg）对巴甫洛夫恐惧调节的影响。训练前服用低剂量莫达非尼（0.75 毫克/公斤）可增强情境恐惧调节的记忆（停药一周后进行测试），而高剂量（75 毫克/公斤）则会破坏记忆。训练前的莫达非尼在任何测试剂量下都不会影响提示调节，训练后立即服用莫达非尼对提示或情境恐惧没有影响。这些结果表明，莫达非尼对记忆的影响比安非他明或可卡因更具选择性，并且对海马依赖性记忆具有特异性。
Modafinil has been shown to promote wakefulness and some studies suggest the drug can improve cognitive function. Because of many similarities, the mechanism of action may be comparable to classical psychostimulants, although the exact mechanisms of modafinil’s actions in wakefulness and cognitive enhancement are unknown. The current study aims to further examine the effects of modafinil as a cognitive enhancer on hippocampus-dependent memory in mice. A high dose of modafinil (75 mg/kg, i.p.) given before training improved acquisition on a Morris water maze. When given only before testing, modafinil did not affect water maze performance. We also examined modafinil (0.075 – 75 mg/kg) on Pavlovian fear conditioning. A low dose of pre-training modafinil (0.75 mg/kg) enhanced memory of contextual fear conditioning (tested off-drug one week later) while a high dose (75 mg/kg) disrupted memory. Pre-training modafinil did not affect cued conditioning at any dose tested, and immediate post-training modafinil had no effect on either cued or contextual fear. These results suggest that modafinil’s effects of memory are more selective than amphetamine or cocaine, and specific to hippocampus-dependent memory.
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DOI：
10.1124/jpet.106.106583
发表时间：
2006-11-01
影响因子：
3.5
作者：
Madras, Bertha K.;Xie, Zhihua;Fischman, Alan J.
通讯作者：
Fischman, Alan J.
影响因子：
6.7
作者：
Ling, Walter;Rawson, Richard;Ling, Walter
通讯作者：
Ling, Walter
影响因子：
1.7
作者：
Béracochéa, D;Cagnard, B;Piérard, C
通讯作者：
Piérard, C
影响因子：
3.4
作者：
Deroche-Gamonet, V;Darnaudéry, M;Piazza, PV
通讯作者：
Piazza, PV
影响因子：
3.6
作者：
Béracochéa, D;Celerier, A;Pierard, C
通讯作者：
Pierard, C