Behavioral models of tinnitus and hyperacusis in animals.

Behavioral models of tinnitus and hyperacusis in animals.
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DOI:
10.3389/fneur.2014.00179
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发表时间:
2014
影响因子:
3.4
通讯作者:
Salvi RJ
Salvi RJ
中科院分区:
医学3区
文献类型:
--
作者:
Hayes SH;Radziwon KE;Stolzberg DJ;Salvi RJ

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耳鸣的幻觉和与听觉过敏相关的声级耐受性降低有很高的共患率,可能是虚弱的条件,目前还没有广泛接受的治疗方法。限制耳鸣和听觉过敏治疗发展的一个因素是缺乏这些疾病的可靠动物行为模型。因此,本综述的目的是强调目前耳鸣和听觉过敏的动物模型,并详细说明每种模型的优缺点。到目前为止,这是第一次包括耳鸣和听觉过敏模型的综述。
The phantom perception of tinnitus and reduced sound-level tolerance associated with hyperacusis have a high comorbidity and can be debilitating conditions for which there are no widely accepted treatments. One factor limiting the development of treatments for tinnitus and hyperacusis is the lack of reliable animal behavioral models of these disorders. Therefore, the purpose of this review is to highlight the current animal models of tinnitus and hyperacusis, and to detail the advantages and disadvantages of each paradigm. To date, this is the first review to include models of both tinnitus and hyperacusis.
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