The role of community advisory boards in community-based HIV clinical trials: a qualitative study from Tanzania.
The role of community advisory boards in community-based HIV clinical trials: a qualitative study from Tanzania.
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DOI：
10.1186/s12910-021-00737-w
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发表时间：
2022-01-08
影响因子：
2.7
通讯作者：
Mmbaga BT
中科院分区：
文献类型：
--
作者：
Pancras G;Sunguya BF;Sirili N;Balandya E;Lyamuya E;Mmbaga BT
社区咨询委员会（CAB）已成为社区参与艾滋病毒临床试验的重要机构，特别是在发展中国家。然而，在包括坦桑尼亚在内的低收入和中等收入国家，关于CAB的作用的经验证据有限。本研究旨在探讨CAB在坦桑尼亚开展的社区艾滋病临床试验中的作用。我们采用现象学方法有目的地选择HIV临床试验利益相关者。这些人包括CAB成员、研究人员和坦桑尼亚的机构审查委员会成员。我们对10名参与者进行了深入访谈（IDI），并对18名参与者进行了三次焦点小组讨论（FGD）。借助MAXQDA 20.2.1版软件对数据进行了主题分析。研究结果表明，在实施以社区为基础的艾滋病毒临床试验的每个阶段，一个功能正常的CAB对其成功至关重要。这种重要性是基于知情同意过程和协议的背景化，管理社区中的谣言，权衡试验风险和收益，提高社区的敏感性，协助参与者招募，追踪和保留。然而，被视为财政受益者而不是社区代表，对CAB成员来说是一个挑战。 这项研究经验表明，在实施以社区为基础的艾滋病毒临床试验的每一个阶段，需要功能CAB。其作用是相互交织的，服务于研究目标，保护社区和试验参与者的利益。在线版本包含补充材料，可通过10.1186/s12910-021-00737-w获得。
Community Advisory Boards (CAB) have become essential organs of involving communities in HIV clinical trials especially in developing countries. However, limited empirical evidence exists on the role of CABs in low and middle-income countries including Tanzania. This study aims at exploring the role of CABs in community-based HIV clinical trials conducted in Tanzania. We adopted a phenomenological approach to purposefully select HIV clinical trial stakeholders. These included CAB members, researchers and Institutional Review Board (IRB) members in Tanzania. We conducted In-depth Interviews (IDIs) with ten participants and three Focus Group Discussions (FGDs) with eighteen participants. The data were thematically analyzed with the aid of MAXQDA software version 20.2.1. The findings indicate that at every stage of implementation of a community-based HIV clinical trial, a functioning CAB is important for its success. This importance is based on contextualization of the informed consent process and protocol, managing rumours in the community, weighing trial risks and benefits, sensitizing the community, assisting participant recruitment, tracing and retention. However, being perceived as financial beneficiaries than community representatives emerged as a challenge to CAB members. The study empirically indicates the need for functioning CABs in every stage of implementation of community-based HIV clinical trials. The roles of which are interwoven in serving research goals and protecting the interests of the community and that of trial participants. The online version contains supplementary material available at 10.1186/s12910-021-00737-w.
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影响因子：
2.2
作者：
Nyirenda D;Sariola S;Gooding K;Phiri M;Sambakunsi R;Moyo E;Bandawe C;Squire B;Desmond N
通讯作者：
Desmond N
DOI：
10.1097/00126334-200308010-00013
发表时间：
2003-08-01
影响因子：
3.6
作者：
Morin, SF;Maiorana, A;Richards, TA
通讯作者：
Richards, TA
影响因子：
1.5
作者：
Cox, LE;Rouff, JR;Abrams, DI
通讯作者：
Abrams, DI
影响因子：
2.7
作者：
Mwinga, Alwyn;Moodley, Keymanthri
通讯作者：
Moodley, Keymanthri
影响因子：
2.8
作者：
Ndaba, Thoko;Taylor, Myra;Mabaso, Musawenkosi
通讯作者：
Mabaso, Musawenkosi