Nanomedicine for safe healing of bone trauma: Opportunities and challenges.
Nanomedicine for safe healing of bone trauma: Opportunities and challenges.
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DOI：
10.1016/j.biomaterials.2017.09.005
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发表时间：
2017-11
期刊：
影响因子：
14
通讯作者：
Mahmoudi M
中科院分区：
文献类型：
--
作者：
Behzadi S;Luther GA;Harris MB;Farokhzad OC;Mahmoudi M
从历史上看，高能量肢体损伤导致严重的软组织创伤和骨丢失通常被认为是无法挽救的，并采用一期截肢术治疗。随着软组织覆盖和神经修复技术的改进，这些损伤现在对保肢手术提出了新的挑战。根据软组织包膜的完整性，高能量肢体创伤易于延迟或不可预测的骨愈合和高感染率。此外，骨科创伤外科医生经常面临稳定和修复大骨缺损的挑战，同时促进最佳环境以防止感染并帮助骨愈合。在过去的十年中，纳米医学在解决骨科创伤固有的两个主要问题（即，高感染风险和低骨重建）。这篇综述提出了一个概述，并讨论了最近的挑战和机遇，以解决重大骨科创伤，通过纳米医学方法。
Historically, high-energy extremity injuries resulting in significant soft-tissue trauma and bone loss were often deemed unsalvageable and treated with primary amputation. With improved soft-tissue coverage and nerve repair techniques, these injuries now present new challenges in limb-salvage surgery. High-energy extremity trauma is pre-disposed to delayed or unpredictable bony healing and high rates of infection, depending on the integrity of the soft-tissue envelope. Furthermore, orthopedic trauma surgeons are often faced with the challenge of stabilizing and repairing large bony defects while promoting an optimal environment to prevent infection and aid bony healing. During the last decade, nanomedicine has demonstrated substantial potential in addressing the two major issues intrinsic to orthopedic traumas (i.e., high infection risk and low bony reconstruction) through combatting bacterial infection and accelerating/increasing the effectiveness of the bone-healing process. This review presents an overview and discusses recent challenges and opportunities to address major orthopedic trauma through nanomedical approaches.
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