The impact of thyroid function on intrauterine insemination outcome--a retrospective analysis.
The impact of thyroid function on intrauterine insemination outcome--a retrospective analysis.
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DOI：
10.1186/1477-7827-12-28
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发表时间：
2014-04-05
期刊：
影响因子：
--
通讯作者：
Ott J
中科院分区：
文献类型：
--
作者：
Jatzko B;Vytiska-Bistorfer E;Pawlik A;Promberger R;Mayerhofer K;Ott J
桥本甲状腺炎是绝经前妇女最常见的内分泌疾病，并与各种妇科问题有关，包括反复流产和不明原因不孕。桥本甲状腺炎对宫内人工授精成功率的影响似乎是可能的，但尚未得到评估。因此，我们的研究目的是回顾性分析甲状腺功能和提示桥本甲状腺炎的标志物对宫内人工授精结果的影响。某三级保健中心540名接受宫内人工授精的妇女的回顾性队列研究。临床妊娠率为主要结局参数。检测以下可能的影响因素：促甲状腺激素（TSH）；甲状腺自身抗体;年龄;身体质量指数；不育类型（原发性/继发性）；奇偶性;男性因素;存在PCO综合征；排卵诱导;卵巢刺激;还有目前的甲状腺药物。临床总妊娠率为6.9%（37/540）。多因素分析显示，年龄、补充甲状腺激素促甲状腺激素（TSH）水平> 2.5 micro-IU/ml、促排卵促绒毛膜促性腺激素（HCG）作为宫内人工授精后妊娠率的影响因素具有显著预测意义（p < 0.05）。接受宫内人工授精的妇女似乎受益于严格的甲状腺激素补充方案，以达到较低的促甲状腺激素水平。
Hashimoto’s thyroiditis is the most common endocrinopathy in premenopausal women, and is associated with various gynecological problems, including recurrent miscarriage and unexplained infertility. A possible influence of Hashimoto’s thyroiditis on the success of intrauterine insemination seems likely, but has not been evaluated as yet. Therefore, the aim of our study was to retrospectively analyze the impact on intrauterine insemination outcome of thyroid function and markers suggestive for Hashimoto’s thyroiditis. Retrospective cohort study in a tertiary care center of 540 women who underwent Intrauterine Insemination. The clinical pregnancy rate was the main outcome parameters. The following possible influencing factors were tested: thyroid-stimulating hormone (TSH); thyroid autoantibodies; age; body mass index; type of sterility (primary/secondary); parity; male factor; presence of PCO syndrome; ovulation induction; ovarian stimulation; and current thyroid medication. The overall clinical pregnancy rate was 6.9% (37/540). Age, thyroid hormone supplementation for thyroid-stimulating hormone (TSH) levels > 2.5 micro-IU/ml, and ovulation induction with HCG were significantly predictive in the multivariate analysis (p < 0.05) as influencing factors for the pregnancy rate after intrauterine insemination. Women undergoing intrauterine insemination seem to benefit from a strict thyroid hormone supplementation regimen in order to achieve lower TSH levels.
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影响因子：
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作者：
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