Cardiac autonomic function during sleep: effects of alcohol dependence and evidence of partial recovery with abstinence.
Cardiac autonomic function during sleep: effects of alcohol dependence and evidence of partial recovery with abstinence.
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DOI：
10.1016/j.alcohol.2014.07.023
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发表时间：
2015-06
期刊：
影响因子：
2.3
通讯作者：
Colrain, Ian M.
中科院分区：
文献类型：
--
作者：
de Zambotti, Massimiliano;Willoughby, Adrian R.;Baker, Fiona C.;Sugarbaker, David S.;Colrain, Ian M.
慢性酒精中毒与心脏和周围自主神经系统（ANS）病理的发展有关。本研究的目的是评估在禁欲的前4个月内ANS功能恢复的程度。15名酗酒者（7名女性）在三个场合进行了研究：在一个月内的排毒，在大约2个月后排毒，并在4个月后排毒。13名对照组受试者（6名女性）也进行了三次研究，研究间隔与酗酒者相匹配。6名酗酒者在初次PSG治疗后48.7 ± 27.9天复发。ANS功能在稳定的非快速眼动睡眠的第一部分进行评估。心率变异性（HRV）的频域功率谱分析产生的变量包括：心率（HR）、总功率（TP;代表总HR变异性的指数）、高频功率（HFa;反映心脏迷走神经调制的指数）、HF占总功率的比例（HFprop交感迷走神经平衡）和HF峰值频率（HFpf;反映呼吸率的指数）。总体而言，高总和高频率变异性和低交感迷走神经平衡和心肌收缩性被认为是促进心血管健康的理想条件。在最初的评估中，酗酒者的HR（p < 0.001）和呼吸频率（p < 0.01）高于对照组，迷走神经活动（HFa; p < 0.01）低于对照组。戒酒4个月后，酗酒者的HR（p = 0.039）和HFa（p = 0.031）出现恢复迹象。初次就诊时TP较高的酗酒者从初次到4个月随访时TP的改善更大（r = 0.75，p < 0.05）。戒酒4个月后，酗酒者的心率和迷走神经对心率变异性的调节明显恢复，有证据表明，心率变异性恢复的程度可能部分取决于酒精依赖相关的心脏ANS系统损伤的程度。这些数据支持了其他研究，这些研究表明，即使是长期依赖的人，禁欲也能在许多ANS、中枢神经系统和行为领域得到恢复。
Chronic alcoholism is associated with the development of cardiac and peripheral autonomic nervous system (ANS) pathology. The aim of the present study was to evaluate the extent to which recovery in ANS function could be demonstrated over the first 4 months of abstinence. Fifteen alcoholics (7 women) were studied on three occasions: within a month of detoxification, at approximately 2 months post-detox, and at 4 months post-detox. Thirteen control subjects (6 women) were also studied on three occasions with inter-study intervals matching those of the alcoholics. Six alcoholics relapsed, 48.7 ± 27.9 days following the initial PSG session. ANS function was assessed in the first part of stable non-rapid eye movement sleep. Frequency-domain power spectral analysis of heart rate variability (HRV) produced variables including: heart rate (HR), total power (TP; an index representing total HR variability), High Frequency power (HFa; an index reflecting cardiac vagal modulation), HF proportion of total power (HFprop sympathovagal balance), and HF peak frequency (HFpf; an index reflecting respiration rate). Overall, high total and high frequency variability and low sympathovagal balance and myocardial contractility are considered as desired conditions to promote cardiovascular health. At initial assessment, alcoholics had a higher HR (p < 0.001) and respiratory rate (p < 0.01), and lower vagal activity (HFa; p < 0.01) than controls. Alcoholics showed evidence of recovery in HR (p = 0.039) and HFa (p = 0.031) with 4 months of abstinence. Alcoholics with higher TP at the initial visit showed a greater improvement in TP from the initial to the 4-month follow-up session (r = 0.75, p < 0.05). Alcoholics showed substantial recovery in HR and vagal modulation of HRV with 4 months of abstinence, with evidence that the extent of recovery in HRV may be partially determined by the extent of alcohol dependence-related insult to the cardiac ANS system. These data support other studies showing recovery in a number of ANS, central nervous system, and behavioral domains with abstinence, even in those with long-term dependence.
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影响因子：
3.4
作者：
Colrain IM;Padilla ML;Baker FC
通讯作者：
Baker FC
DOI：
10.1111/acer.12384
发表时间：
2014-05
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
de Zambotti M;Baker FC;Sugarbaker DS;Nicholas CL;Trinder J;Colrain IM
通讯作者：
Colrain IM
影响因子：
5.1
作者：
BARTER, F;TANNER, AR
通讯作者：
TANNER, AR
DOI：
10.1097/01.alc.0000081622.03973.57
发表时间：
2003-08-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Currie, SR;Clark, S;Malhotra, S
通讯作者：
Malhotra, S
影响因子：
3.1
作者：
Ganesha S;Thirthalli J;Muralidharan K;Benegal V;Gangadhar BN
通讯作者：
Gangadhar BN