Role of RHO family interacting cell polarization regulators (RIPORs) in health and disease: Recent advances and prospects.
Role of RHO family interacting cell polarization regulators (RIPORs) in health and disease: Recent advances and prospects.
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RHO家族相互作用细胞极化调节因子（RIPOR）在健康和疾病中的作用：最新进展和前景
DOI：
10.7150/ijbs.65457
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发表时间：
2022
影响因子：
9.2
通讯作者：
Gao K
中科院分区：
文献类型：
--
作者：
Lv Z;Ding Y;Cao W;Wang S;Gao K
RHO GTPase家族被认为在细胞生长、迁移和极化中起关键作用。近年来，人们对RHO GTPases的调控因子和效应因子进行了广泛的研究。然而，RHO家族相互作用细胞极化调节剂（RIPORs）是最近发现的RHO调控蛋白家族，很少受到关注。RIPOR蛋白，即RIPOR1-3，通过RHO结合基序直接与RHO蛋白（A、B和C）结合，对RHO活性产生抑制作用，从而对RHO调控的细胞功能产生负面影响。此外，在趋化因子的刺激下，上游蛋白激酶磷酸化RIPORs，这种磷酸化不仅影响其亚细胞定位，还影响其与RHO蛋白的相互作用，改变RHO下游靶点的激活，最终影响细胞极性和迁移。在这篇综述中，我们综述了近年来关于RIPOR蛋白在调节rho依赖的定向运动免疫反应和其他病理生理功能中的功能的研究。
The RHO GTPase family has been suggested to play critical roles in cell growth, migration, and polarization. Regulators and effectors of RHO GTPases have been extensively explored in recent years. However, little attention has been given to RHO family interacting cell polarization regulators (RIPORs), a recently discovered protein family of RHO regulators. RIPOR proteins, namely, RIPOR1-3, bind directly to RHO proteins (A, B and C) via a RHO-binding motif and exert suppressive effects on RHO activity, thereby negatively influencing RHO-regulated cellular functions. In addition, RIPORs are phosphorylated by upstream protein kinases under chemokine stimulation, and this phosphorylation affects not only their subcellular localization but also their interaction with RHO proteins, altering the activation of RHO downstream targets and ultimately impacting cell polarity and migration. In this review, we provide an overview of recent studies on the function of RIPOR proteins in regulating RHO-dependent directional movement in immune responses and other pathophysiological functions.
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影响因子：
7.3
作者：
Gardino, Alexandra K.;Yaffe, Michael B.
通讯作者：
Yaffe, Michael B.
DOI：
10.1007/978-4-431-56550-5_22
发表时间：
2017-01-01
期刊：
DREBRIN: FROM STRUCTURE AND FUNCTION TO PHYSIOLOGICAL AND PATHOLOGICAL ROLES
影响因子：
--
作者：
Krauss, Robert S.
通讯作者：
Krauss, Robert S.
DOI：
10.1073/pnas.1401950111
发表时间：
2014-07-08
影响因子：
11.1
作者：
Diaz-Horta, Oscar;Subasioglu-Uzak, Asli;Tekin, Mustafa
通讯作者：
Tekin, Mustafa
影响因子：
3.5
作者：
Goutman JD;Elgoyhen AB;Gómez-Casati ME
通讯作者：
Gómez-Casati ME
影响因子：
14.9
作者：
Hornbeck PV;Zhang B;Murray B;Kornhauser JM;Latham V;Skrzypek E
通讯作者：
Skrzypek E