How Early Life Adversity Influences Defensive Circuitry.
How Early Life Adversity Influences Defensive Circuitry.
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DOI：
10.1016/j.tins.2020.02.001
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发表时间：
2020-04
影响因子：
15.9
通讯作者：
Gould E
中科院分区：
文献类型：
--
作者：
Murthy S;Gould E
儿童时期的虐待增加了人类发展为焦虑症的可能性。啮齿动物的早期生活逆境（ELA）范式对直接和非特异性威胁产生持久的回避和抑制反应，统称为防御行为。这种方法提供了彻底调查潜在机制的机会，这是目前正在进行的一项工作。在这篇综述中，我们考虑到越来越多的文献表明ELA改变了与防御行为相关的大脑区域神经元的节律性放电，以及潜在的神经元、胶质和细胞外基质对该回路功能变化的贡献。我们还考虑了啮齿动物的ELA研究如何告诉我们人类的易感和弹性结果。
Childhood maltreatment increases the likelihood of developing anxiety disorders in humans. Early life adversity (ELA) paradigms in rodents produce lasting increases in avoidant and inhibitory responses to both immediate and nonspecific threats, collectively referred to as defensive behaviors. This approach provides an opportunity to thoroughly investigate the underlying mechanisms, an effort that is currently under way. In this review, we consider the growing literature indicating that ELA alters the rhythmic firing of neurons in brain regions associated with defensive behavior, as well as potential neuronal, glial, and extracellular matrix contributions to functional changes in this circuitry. We also consider how ELA studies in rodents may inform us about both susceptible and resilient outcomes in humans.
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影响因子：
3.3
作者：
Andersen SL
通讯作者：
Andersen SL
影响因子：
16.2
作者：
Amilhon, Benedicte;Huh, Carey Y. L.;Williams, Sylvain
通讯作者：
Williams, Sylvain
影响因子：
64.5
作者：
Allsop SA;Wichmann R;Mills F;Burgos-Robles A;Chang CJ;Felix-Ortiz AC;Vienne A;Beyeler A;Izadmehr EM;Glober G;Cum MI;Stergiadou J;Anandalingam KK;Farris K;Namburi P;Leppla CA;Weddington JC;Nieh EH;Smith AC;Ba D;Brown EN;Tye KM
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Tye KM
影响因子：
7.6
作者：
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通讯作者：
Stork, Oliver
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2.7
作者：
Danielewicz, Joanna;Trenk, Aleksandra;Hess, Grzegorz
通讯作者：
Hess, Grzegorz