Effects of lactobacilli with different regulatory behaviours on tight junctions in mice with dextran sodium sulphate-induced colitis
Effects of lactobacilli with different regulatory behaviours on tight junctions in mice with dextran sodium sulphate-induced colitis
复制标题
不同调节行为的乳酸杆菌对右旋糖酐硫酸钠诱导结肠炎小鼠紧密连接的影响
DOI：
10.1016/j.jff.2018.05.044
复制
发表时间：
2018-08
影响因子：
5.6
通讯作者：
Chen Wei
中科院分区：
文献类型：
--
作者：
Wang Gang;Xu Qi;Jin Xing;Hang Feng;Liu Zhenmin;Zhao Jianxin;Zhang Hao;Chen Wei
在这项研究中，六株乳酸菌在体外对哺乳动物细胞的紧密连接（TJ）蛋白表现出不同的调节作用，用于治疗右旋糖酐硫酸钠（DSS）诱导的小鼠结肠炎。与体外结果一致，不同菌株对肠屏障TJ修复以及缓解结肠炎症状（包括疾病活动指数、组织损伤和炎症）表现出不同的效果。乳酸杆菌在缓解小鼠结肠炎综合征的能力方面表现出显着的种间和种内差异，这与其对 TJ 蛋白恢复的作用高度相关，尽管还应考虑细菌对免疫系统和 SCFA 的影响。因此，与 TJ 恢复相关的益生菌是治疗结肠炎的潜在候选者。 TJ恢复能力应该是筛选治疗结肠炎的益生菌的重要目标之一。
In this study, six strains ofLactobacillusexhibiting different regulatory effects on the tight junction (TJ) proteins of mammalian cellsin vitrowere used in the treatment of mice with colitis induced by dextran sodium sulphate (DSS). Consistent with the resultsin vitro, different strains displayed different effects on repairment of TJs in the intestinal barrier, as well as alleviation on symptoms of colitis including disease activity index, tissue damage and inflammation. The lactobacilli showed significant inter- and intra-species differences in their ability to relieve the syndrome of colitis in mice, which were highly correlated with their effects on TJ protein recovery, although the impacts of bacteria on immune system and SCFAs should also be considered. Therefore, probiotics associated with TJ recovery are potential candidates for the treatment of colitis. The capacity for TJ recovery should be one of the important targets in the screening of probiotics for colitis treatment.
登录
查看更多内容
影响因子：
--
作者：
Fruet AC;Seito LN;Rall VL;Di Stasi LC
通讯作者：
Di Stasi LC
影响因子：
6.1
作者：
Gang Wang;Xiangfei Li;Jianxin Zhao;Hao Zhang;Wei Chen
通讯作者：
Gang Wang;Xiangfei Li;Jianxin Zhao;Hao Zhang;Wei Chen
影响因子：
14.2
作者：
Groschwitz, Katherine R.;Hogan, Simon P.
通讯作者：
Hogan, Simon P.
DOI：
10.1016/j.jcmgh.2017.03.010
发表时间：
2017-07
影响因子：
7.2
作者：
Oh-Oka K;Kojima Y;Uchida K;Yoda K;Ishimaru K;Nakajima S;Hemmi J;Kano H;Fujii-Kuriyama Y;Katoh R;Ito H;Nakao A
通讯作者：
Nakao A
影响因子：
5.2
作者：
A. J. Watson;C. Duckworth;Yanfang Guan;M. Montrose
通讯作者：
A. J. Watson;C. Duckworth;Yanfang Guan;M. Montrose