Mood Disorders in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study.
Mood Disorders in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study.
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DOI：
10.1002/art.39111
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发表时间：
2015-07
影响因子：
13.3
通讯作者：
Farewell, Vernon
中科院分区：
文献类型：
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作者：
Hanly, John G.;Su, Li;Urowitz, Murray B.;Romero-Diaz, Juanita;Gordon, Caroline;Bae, Sang-Cheol;Bernatsky, Sasha;Clarke, Ann E.;Wallace, Daniel J.;Merrill, Joan T.;Isenberg, David A.;Rahman, Anisur;Ginzler, Ellen M.;Petri, Michelle;Bruce, Ian N.;Dooley, M. A.;Fortin, Paul;Gladman, Dafna D.;Sanchez-Guerrero, Jorge;Steinsson, Kristjan;Ramsey-Goldman, Rosalind;Khamashta, Munther A.;Aranow, Cynthia;Alarcon, Graciela S.;Fessler, Barri J.;Manzi, Susan;Nived, Ola;Sturfelt, Gunnar K.;Zoma, Asad A.;van Vollenhoven, Ronald F.;Ramos-Casals, Manuel;Ruiz-Irastorza, Guillermo;Lim, S. Sam;Kalunian, Kenneth C.;Inanc, Murat;Kamen, Diane L.;Peschken, Christine A.;Jacobsen, Soren;Askanase, Anca;Theriault, Chris;Thompson, Kara;Farewell, Vernon
在一个多种族、前瞻性、初始队列的SLE患者中，确定心境障碍的发生频率、临床和自身抗体相关性以及结局。每年评估患者的情绪障碍（根据DSM-IV的4种类型）和18种其他神经精神（NP）事件。收集总体疾病活动度（SLEDAI-2K）、SLICC/ACR损伤指数（SDI）和SF-36子量表、精神（MCS）和身体（PCS）分量总评。适当时使用至事件发生时间、线性和有序回归以及多状态模型。在1，827例SLE患者中，88.9%为女性，48.9%为白人，平均± SD年龄35.1±13.3岁，病程5.6±4.8个月，随访4.73±3.45年。在研究期间，863例（47.2%）患者发生了1，627起NP事件。232/1827例（12.7%）患者发生情绪障碍，98/256例（38.3%）事件归因于SLE。10年后任何心境障碍的估计累积发生率为17.7%（95%CI=[15.1%，20.2%]）。同时发生NP事件的患者发生心境障碍的风险更高（p ≤ 0.01），亚洲人种/种族（p=0.01）和免疫抑制药物（p=0.003）的风险更低。情绪障碍与较低的心理健康子量表和MCS评分相关，但与SLEDAI-2K、SDI评分或狼疮自身抗体无关。168/232例（72.4%）抑郁症患者使用抗抑郁药。117/232例（50.4%）患者中126/256例（49.2%）心境障碍消退。情绪障碍是SLE患者中第二常见的NP事件，对HRQoL有负面影响，并随时间推移而改善。缺乏与全球SLE疾病活动性、累积性器官损伤和狼疮自身抗体的相关性，强调了其多因素病因和非狼疮特异性治疗的作用。
To determine the frequency, clinical and autoantibody associations and outcome of mood disorders in a multi-ethnic/racial, prospective, inception cohort of SLE patients. Patients were assessed annually for mood disorders (4 types as per DSM-IV) and 18 other neuropsychiatric (NP) events. Global disease activity (SLEDAI-2K), SLICC/ACR damage index (SDI) and SF-36 subscale, mental (MCS) and physical (PCS) component summary scores were collected. Time to event, linear and ordinal regressions and multi-state models were used as appropriate. Of 1,827 SLE patients, 88.9% were female, 48.9% Caucasian, mean ± SD age 35.1±13.3 years, disease duration 5.6±4.8 months and follow-up 4.73±3.45 years. Over the study 863 (47.2%) patients had 1,627 NP events. Mood disorders occurred in 232/1827 (12.7%) patients and 98/256 (38.3%) events were attributed to SLE. The estimated cumulative incidence of any mood disorder after 10 years was 17.7% (95%CI=[15.1%,20.2%]). There was a greater risk of mood disorder in patients with concurrent NP events (p ≤ 0.01) and lower risk with Asian race/ethnicity (p=0.01) and immunosuppressive drugs (p=0.003). Mood disorders were associated with lower mental health subscale and MCS scores but not with SLEDAI-2K, SDI scores or lupus autoantibodies. Antidepressants were used in 168/232 (72.4%) patients with depression. 126/256 (49.2%) mood disorders resolved in 117/232 (50.4%) patients. Mood disorders, the second most frequent NP event in SLE patients, have a negative impact on HRQoL and improve over time. The lack of association with global SLE disease activity, cumulative organ damage and lupus autoantibodies emphasize their multifactorial etiology and a role for non-lupus specific therapies.
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影响因子：
27.4
作者：
Hanly JG;Urowitz MB;Su L;Bae SC;Gordon C;Wallace DJ;Clarke A;Bernatsky S;Isenberg D;Rahman A;Alarcón GS;Gladman DD;Fortin PR;Sanchez-Guerrero J;Romero-Diaz J;Merrill JT;Ginzler E;Bruce IN;Steinsson K;Khamashta M;Petri M;Manzi S;Dooley MA;Ramsey-Goldman R;Van Vollenhoven R;Nived O;Sturfelt G;Aranow C;Kalunian K;Ramos-Casals M;Zoma A;Douglas J;Thompson K;Farewell V;Systemic Lupus International Collaborating Clinics (SLICC)
通讯作者：
Systemic Lupus International Collaborating Clinics (SLICC)
影响因子：
3.1
作者：
Andrade, L;Caraveo-Anduaga, JJ;Wittchen, HU
通讯作者：
Wittchen, HU
影响因子：
--
作者：
Hanly, J. G.;Urowitz, M. B.;Merrill, J. T.
通讯作者：
Merrill, J. T.
影响因子：
27.4
作者：
Hanly, J. G.;Urowitz, M. B.;Farewell, V.
通讯作者：
Farewell, V.
影响因子：
3.3
作者：
Kellner, Erinn S.;Lee, Pui Y.;Reeves, Westley H.
通讯作者：
Reeves, Westley H.