Exo- and Endo-cannabinoids in Depressive and Suicidal Behaviors.
Exo- and Endo-cannabinoids in Depressive and Suicidal Behaviors.
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DOI：
10.3389/fpsyt.2021.636228
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发表时间：
2021
影响因子：
4.7
通讯作者：
Vinod KY
中科院分区：
文献类型：
--
作者：
Mannekote Thippaiah S;Iyengar SS;Vinod KY
大麻(大麻)早在几千年前就为人类所知，但直到最近，人们对它的神经生理影响知之甚少。在过去的二十年中，临床前和临床研究无可争议地支持了这一临床命题，即内源性大麻素系统在许多神经精神障碍的发病机制中发挥着重要作用，包括情绪障碍和成瘾障碍。在这篇综述中，我们讨论了外源性和内源性大麻素的现有知识，以及内源性大麻素系统在抑郁和自杀行为中的作用。这个系统的功能障碍位于大脑的前额叶皮质和边缘结构等区域，与情绪调节、冲动和决策有关，可能会增加负面情绪和认知以及自杀的风险。这里讨论的文献还表明，内源性大麻素系统可能是治疗这些神经精神疾病的一个可行的靶点。
Cannabis (marijuana) has been known to humans for thousands of years but its neurophysiological effects were sparsely understood until recently. Preclinical and clinical studies in the past two decades have indisputably supported the clinical proposition that the endocannabinoid system plays an important role in the etiopathogeneses of many neuropsychiatric disorders, including mood and addictive disorders. In this review, we discuss the existing knowledge of exo- and endo-cannabinoids, and role of the endocannabinoid system in depressive and suicidal behavior. A dysfunction in this system, located in brain regions such as prefrontal cortex and limbic structures is implicated in mood regulation, impulsivity and decision-making, may increase the risk of negative mood and cognition as well as suicidality. The literature discussed here also suggests that the endocannabinoid system may be a viable target for treatments of these neuropsychiatric conditions.
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影响因子：
10.6
作者：
Autry, Anita E.;Adachi, Megumi;Cheng, Pengfei;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
n-芳基多烯酰基甘氨酸，GPR55的另一种内源性激动剂。
DOI：
10.1016/j.bbrc.2017.07.038
发表时间：
2017-09-02
影响因子：
3.1
作者：
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通讯作者：
Abood ME
影响因子：
7.3
作者：
Chen, X. P.;Yang, W.;Zhou, N. M.
通讯作者：
Zhou, N. M.
影响因子：
4.7
作者：
Basavarajappa BS;Shivakumar M;Joshi V;Subbanna S
通讯作者：
Subbanna S
影响因子：
2.7
作者：
da Costa Daniele, Thiago Medeiros;Carvalhedo de Bruin, Pedro Felipe;Sales de Bruin, Veralice Meireles
通讯作者：
Sales de Bruin, Veralice Meireles