Development of white matter pathways in typically developing preadolescent children.
Development of white matter pathways in typically developing preadolescent children.
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DOI：
10.1016/j.brainres.2012.05.035
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发表时间：
2012-07-23
期刊：
影响因子：
2.9
通讯作者：
Sandman CA
中科院分区：
文献类型：
--
作者：
Muftuler LT;Davis EP;Buss C;Solodkin A;Su MY;Head KM;Hasso AN;Sandman CA
大脑中主要神经元重排的第一阶段发生在产前时期。虽然大脑在整个童年时期继续成熟，但突触过度产生和消除的关键第二阶段发生在青春期前。尽管这一发育阶段的重要性，很少有研究评估在此期间发生的神经变化。在这项研究中，MRI扩散张量成像数据从一个正常的样本126个青春期前儿童（59个女孩和67个男孩）之间的6和10岁的分析，以表征年龄关系的白色物质的微观结构。基于束的空间统计（TBSS）方法被用于全脑分析的白色物质束没有先验假设的年龄相关的差异的位置。我们的研究结果表明，在大多数主要的纤维束双边和沿着整个身体的束显着的年龄相关的差异。相比之下，在扣带回的海马旁区的水平上的发展差异，只观察到在右半球。我们认为，这些年龄关系与广泛的分布在青春期前的几年可能有关的认知和社会行为的实施需要一个正常的发展到成年。
The first phase of major neuronal rearrangements in the brain takes place during the prenatal period. While the brain continues maturation throughout childhood, a critical second phase of synaptic overproduction and elimination takes place during the preadolescent period. Despite the importance of this developmental phase, few studies have evaluated neural changes taking place during this period. In this study, MRI Diffusion Tensor Imaging data from a normative sample of 126 preadolescent children (59 girls and 67 boys) between the ages of 6 and 10 years were analyzed in order to characterize age-relationships in the white matter microstructure. Tract Based Spatial Statistics (TBSS) method was used for whole brain analysis of white matter tracts without a priori assumption about the location of age associated differences. Our results demonstrate significant age-associated differences in most of the major fiber tracts bilaterally and along the whole body of the tracts. In contrast, developmental differences in the cingulum at the level of the parahippocampal region were only observed in the right hemisphere. We suggest that these age-relationships with a widespread distribution seen during the preadolescent years maybe relevant for the implementation of cognitive and social behaviors needed for a normal development into adulthood.
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