Genome-wide comparison of genes involved in the biosynthesis, metabolism, and signaling of juvenile hormone between silkworm and other insects.
Genome-wide comparison of genes involved in the biosynthesis, metabolism, and signaling of juvenile hormone between silkworm and other insects.
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家蚕和其他昆虫参与保幼激素生物合成、代谢和信号传导的基因的全基因组比较
DOI：
10.1590/s1415-47572014005000006
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发表时间：
2014-06
影响因子：
2.1
通讯作者：
Xia Q
中科院分区：
文献类型：
--
作者：
Cheng D;Meng M;Peng J;Qian W;Kang L;Xia Q
保幼激素（JH）参与昆虫幼虫蜕皮和变态的调节。在此，我们全面地鉴定了家蚕中55个参与JH生物合成、代谢和信号传导的基因，以及黑腹果蝇中35个、冈比亚按蚊中35个、意大利蜜蜂中36个、赤拟谷盗中47个和百灵鸟中44个基因。比较分析表明，参与甲羟戊酸（MVA）途径早期步骤、JH生物合成的神经肽调节或JH信号传导的每个基因在B中均为单拷贝。mori和其他调查的昆虫，表明这些JH相关的途径或步骤可能在所有调查的昆虫中保守。然而，每个基因参与类异戊二烯分支的JH生物合成和JH代谢，以及FPPS基因催化的最后一步的MVA途径的JH生物合成，表现出明显的复制在鳞翅目，包括B。mori和D.百灵鸟。基因芯片和实时荧光定量RT-PCR分析表明，不同拷贝的JH相关基因在幼虫生长和变态过程中呈现不同的表达变化，与JH滴度的动态变化相关。这些结果表明，JH相关基因的复制变异可能与鳞翅目和其他昆虫目之间JH类型的变异在进化上相关。这些结果为进一步研究B细胞中JH相关基因的功能提供了有用的线索。桑和其他昆虫。
Juvenile hormone (JH) contributes to the regulation of larval molting and metamorphosis in insects. Herein, we comprehensively identified 55 genes involved in JH biosynthesis, metabolism and signaling in the silkworm (Bombyx mori) as well as 35 in Drosophila melanogaster, 35 in Anopheles gambiae, 36 in Apis mellifera, 47 in Tribolium castaneum, and 44 in Danaus plexippus. Comparative analysis showed that each gene involved in the early steps of the mevalonate (MVA) pathway, in the neuropeptide regulation of JH biosynthesis, or in JH signaling is a single copy in B. mori and other surveyed insects, indicating that these JH-related pathways or steps are likely conserved in all surveyed insects. However, each gene participating in the isoprenoid branch of JH biosynthesis and JH metabolism, together with the FPPS genes for catalyzing the final step of the MVA pathway of JH biosynthesis, exhibited an obvious duplication in Lepidoptera, including B. mori and D. plexippus. Microarray and real-time RT-PCR analysis revealed that different copies of several JH-related genes presented expression changes that correlated with the dynamics of JH titer during larval growth and metamorphosis. Taken together, the findings suggest that duplication-derived copy variation of JH-related genes might be evolutionarily associated with the variation of JH types between Lepidoptera and other insect orders. In conclusion, our results provide useful clues for further functional analysis of JH-related genes in B. mori and other insects.
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影响因子：
64.8
作者：
Dasmahapatra, Kanchon K.;Walters, James R.;Briscoe, Adriana D.;Davey, John W.;Whibley, Annabel;Nadeau, Nicola J.;Zimin, Aleksey V.;Hughes, Daniel S. T.;Ferguson, Laura C.;Martin, Simon H.;Salazar, Camilo;Lewis, James J.;Adler, Sebastian;Ahn, Seung-Joon;Baker, Dean A.;Baxter, Simon W.;Chamberlain, Nicola L.;Chauhan, Ritika;Counterman, Brian A.;Dalmay, Tamas;Gilbert, Lawrence E.;Gordon, Karl;Heckel, David G.;Hines, Heather M.;Hoff, Katharina J.;Holland, Peter W. H.;Jacquin-Joly, Emmanuelle;Jiggins, Francis M.;Jones, Robert T.;Kapan, Durrell D.;Kersey, Paul;Lamas, Gerardo;Lawson, Daniel;Mapleson, Daniel;Maroja, Luana S.;Martin, Arnaud;Moxon, Simon;Palmer, William J.;Papa, Riccardo;Papanicolaou, Alexie;Pauchet, Yannick;Ray, David A.;Rosser, Neil;Salzberg, Steven L.;Supple, Megan A.;Surridge, Alison;Tenger-Trolander, Ayse;Vogel, Heiko;Wilkinson, Paul A.;Wilson, Derek;Yorke, James A.;Yuan, Furong;Balmuth, Alexi L.;Eland, Cathlene;Gharbi, Karim;Thomson, Marian;Gibbs, Richard A.;Han, Yi;Jayaseelan, Joy C.;Kovar, Christie;Mathew, Tittu;Muzny, Donna M.;Ongeri, Fiona;Pu, Ling-Ling;Qu, Jiaxin;Thornton, Rebecca L.;Worley, Kim C.;Wu, Yuan-Qing;Linares, Mauricio;Blaxter, Mark L.;Ffrench-Constant, Richard H.;Joron, Mathieu;Kronforst, Marcus R.;Mullen, Sean P.;Reed, Robert D.;Scherer, Steven E.;Richards, Stephen;Mallet, James;McMillan, W. Owen;Jiggins, Chris D.
通讯作者：
Jiggins, Chris D.
影响因子：
1.6
作者：
Furuta, Kenjiro;Ichikawa, Akio;Shiotsuki, Takahiro
通讯作者：
Shiotsuki, Takahiro
影响因子：
56.9
作者：
KATAOKA, H;TOSCHI, A;KRAMER, SJ
通讯作者：
KRAMER, SJ
MET 是家蚕变态过程中 20-羟基蜕皮激素发挥最大作用所必需的
影响因子：
3.7
作者：
Guo E;He Q;Liu S;Tian L;Sheng Z;Peng Q;Guan J;Shi M;Li K;Gilbert LI;Wang J;Cao Y;Li S
通讯作者：
Li S
影响因子：
4.8
作者：
Li, Yiping;Zhang, Zhaolin;Palli, Subba R.
通讯作者：
Palli, Subba R.