Perinatal blood biomarkers for the identification of brain injury in very low birth weight growth-restricted infants.
Perinatal blood biomarkers for the identification of brain injury in very low birth weight growth-restricted infants.
复制标题
围产期血液生物标志物用于鉴别极低出生体重生长受限婴儿的脑损伤。
DOI：
10.1038/s41372-021-01112-8
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Graham EM
中科院分区：
文献类型：
--
作者：
Yue SL;Eke AC;Vaidya D;Northington FJ;Everett AD;Graham EM
为了确定在分娩时和出生后不久测量的血液生物标记物是否可以确定生长受限婴儿是否有发展成严重脑损伤的风险。在一组极低出生体重儿的队列中，将胎儿生长受限(FGR)(出生体重为10%)与非FGR新生儿进行比较，并在FGR组中将有脑损伤的与无脑损伤的进行比较。在分娩时和出生后前5天每天检测脐带血中的生物标志物。FGR患者血清IL-6、IL-8、IL-10水平显著升高，而血管内皮生长因子(VEGF)水平显著降低。FGR和脑损伤与IL-6、IL-8、IL-10和胶质纤维酸性蛋白(GFAP)水平显著升高有关。白细胞介素2可能参与了一个共同的途径，导致生长受限和脑损伤的发生，而GFAP可能有助于在这个生长受限组中识别脑损伤。在分娩时脐带血和出生后新生儿血清中检测的生物标记物可以确定生长受限婴儿有发展成严重脑损伤的风险。
To determine if blood biomarkers measured at delivery and shortly after birth can identify growth restricted infants at risk for developing severe brain injury. In a cohort of very low birth weight neonates, fetal growth restricted (FGR) (birth weight < 10%) were compared to non-FGR neonates, and within the FGR group those with brain injury were compared to those without. Biomarkers were measured in cord blood at delivery, and daily for the 1st 5 days of life. FGR was associated with significantly higher levels of interleukin (IL)-6, IL-8, IL-10 and lower levels of vascular endothelial growth factor (VEGF). FGR and brain injury were associated with significantly higher levels of IL-6, IL-8, IL-10 and glial fibrillary acidic protein (GFAP). Interleukins may be involved in a common pathway contributing to both the development of growth restriction and brain injury, and GFAP may help identify brain injury within this growth restricted group. Biomarkers measured in cord blood at delivery and neonatal serum after birth may identify growth restricted infants at risk for developing severe brain injury.
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DOI：
10.1111/j.1479-828x.2010.01192.x
发表时间：
2010-08-01
影响因子：
1.7
作者：
White, Christopher R. H.;Doherty, Dorota A.;Pennell, Craig E.
通讯作者：
Pennell, Craig E.
早产婴儿的脑损伤：破坏性和发育障碍的复杂汞合金。
影响因子：
48
作者：
Volpe, Joseph J.
通讯作者：
Volpe, Joseph J.
影响因子：
3.4
作者：
Garcia JM;Stillings SA;Leclerc JL;Phillips H;Edwards NJ;Robicsek SA;Hoh BL;Blackburn S;Doré S
通讯作者：
Doré S
影响因子：
9.8
作者：
Stewart, Amanda;Tekes, Aylin;Huisman, Thierry A. G. M.;Jennings, Jacky M.;Allen, Marilee C.;Northington, Frances J.;Everett, Allen D.;Graham, Ernest M.
通讯作者：
Graham, Ernest M.
影响因子：
1.1
作者：
Lausten-Thomsen, Ulrik;Olsen, Marianne;Schmiegelow, Kjeld
通讯作者：
Schmiegelow, Kjeld