Parvalbumin increases in the medial and lateral geniculate nuclei of aged rhesus macaques.
Parvalbumin increases in the medial and lateral geniculate nuclei of aged rhesus macaques.
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DOI：
10.3389/fnagi.2013.00069
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发表时间：
2013
影响因子：
4.8
通讯作者：
Recanzone GH
中科院分区：
文献类型：
--
作者：
Gray DT;Rudolph ML;Engle JR;Recanzone GH
随着年龄的增长，猕猴听觉系统皮层下听觉结构中表达钙结合蛋白小白蛋白（PV）的神经元密度增加。然而，尚不清楚这些增加是否发生在听觉系统的丘脑分区，内侧膝状体核（MGN）。此外，目前还不清楚这些与年龄有关的变化是特定于猕猴的听觉系统，还是普遍适用于其他感觉系统。为了解决这些问题，PV免疫反应的内侧和外侧膝状体核（LGN）从7个恒河猴的年龄范围从15至35进行了评估。使用无偏体视学抽样技术分别计算了MGN的三个分区和LGN的六个层中PV表达神经元的密度。我们发现，腹侧和magnocellular细分的MGN和所有六层的LGN增加他们的PV的表达随着年龄的增长，虽然在MGN的增加幅度大于LGN。总之，这些结果表明，MGN显示PV表达的年龄相关性增加，如在整个猕猴上行听觉系统中所见，视觉系统的类似区域显示较小的增加。我们的结论是，虽然感觉系统之间有一些相似之处，与年龄相关的神经化学变化，整个猕猴听觉系统不能完全推广到其他感觉系统。
Subcortical auditory structures in the macaque auditory system increase their densities of neurons expressing the calcium binding protein parvalbumin (PV) with age. However, it is unknown whether these increases occur in the thalamic division of the auditory system, the medial geniculate nucleus (MGN). Furthermore, it is also unclear whether these age-related changes are specific to the macaque auditory system or are generalized to other sensory systems. To address these questions, the PV immunoreactivity of the medial and lateral geniculate nuclei (LGN) from seven rhesus macaques ranging in age from 15 to 35 was assessed. Densities of PV expressing neurons in the three subdivisions of the MGN and the six layers of the LGN were calculated separately using unbiased stereological sampling techniques. We found that the ventral and magnocellular subdivisions of the MGN and all six layers of the LGN increased their expressions of PV with age, although increases in the MGN were greater in magnitude than in the LGN. Together, these results suggest that the MGN shows age-related increases in PV expression as is seen throughout the macaque ascending auditory system, and that the analogous region of the visual system shows smaller increases. We conclude that, while there are some similarities between sensory systems, the age-related neurochemical changes seen throughout the macaque auditory system cannot be fully generalized to other sensory systems.
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影响因子：
2.5
作者：
DEMEULEMEESTER, H;VANDESANDE, F;POCHET, R
通讯作者：
POCHET, R
影响因子：
1.4
作者：
Hatano, Miyako;Furukawa, Mitsuru;Ito, Makoto
通讯作者：
Ito, Makoto
影响因子：
2.5
作者：
Gray, Daniel T.;Engle, James R.;Recanzone, Gregg H.
通讯作者：
Recanzone, Gregg H.
影响因子：
2.5
作者：
Gray, Daniel T.;Engle, James R.;Recanzone, Gregg H.
通讯作者：
Recanzone, Gregg H.
影响因子：
2.5
作者：
de la Mothe, LA;Blumell, S;Hackett, TA
通讯作者：
Hackett, TA