Relationship between grip strength and newly diagnosed nonalcoholic fatty liver disease in a large-scale adult population.
Relationship between grip strength and newly diagnosed nonalcoholic fatty liver disease in a large-scale adult population.
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DOI：
10.1038/srep33255
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发表时间：
2016-09-12
影响因子：
4.6
通讯作者：
Niu K
中科院分区：
文献类型：
--
作者：
Meng G;Wu H;Fang L;Li C;Yu F;Zhang Q;Liu L;Du H;Shi H;Xia Y;Guo X;Liu X;Bao X;Su Q;Gu Y;Yang H;Bin Yu;Wu Y;Sun Z;Niu K
肌肉力量的增强通常与胰岛素敏感性和分泌的改善、脂质代谢的控制以及肌因子分泌的增加有关。这些因素已经成为参与非酒精性脂肪性肝病（NAFLD）发展和进展的重要机制，这意味着肌肉力量可能是NAFLD的有用预测因子。我们的目的是在大规模的成人人群中评估握力（GS）和NAFLD之间的关系。GS采用电子握力计评估，NAFLD采用肝脏超声诊断。多元Logistic回归分析用于评估每个体重的GS四分位数与NAFLD患病率之间的关系。在调整了潜在的混杂因素后，在GS的四分位数中，总体NAFLD、丙氨酸转氨酶水平正常的NAFLD和丙氨酸转氨酶水平升高的NAFLD（95%置信区间）为1.00（参考），0.89（0.78，1.01），0.77（0.67，0.89）和0.67（0.57，0.79）; 1.00（参考），0.91（0.80，1.04），0.79（0.68，0.92）和0.72（0.61，0.85）; 1.00（参考），0.77（0.61，0.98），0.67（0.51，0.86）和0.53（0.40，0.71）（所有趋势P < 0.01）。这是第一项研究表明GS增加与NAFLD的患病率降低独立相关。
Enhanced muscle strength is often related to improved insulin sensitivity and secretion, control of lipid metabolism, and increased secretion of myokines. These factors have emerged as important mechanisms involved in the development and progression of nonalcoholic fatty liver disease (NAFLD), implying that muscle strength may be a useful predictor for NAFLD. We aimed to assess the relationship between grip strength (GS) and NAFLD in a large-scale adult population. GS was assessed using an electronic hand-grip dynamometer, and NAFLD was diagnosed by the liver ultrasonography. Multiple logistic regression analysis was used to assess the relationship between the quartiles of GS per body weight and the prevalence of NAFLD. After adjusting for potentially confounding factors, the odds ratios (95% confidence interval) for overall NAFLD, NAFLD with normal alanine aminotransferase levels, and NAFLD with elevated alanine aminotransferase levels across the quartiles of GS were 1.00 (reference), 0.89 (0.78, 1.01), 0.77 (0.67, 0.89), and 0.67 (0.57, 0.79); 1.00 (reference), 0.91 (0.80, 1.04), 0.79 (0.68, 0.92), and 0.72 (0.61, 0.85); 1.00 (reference), 0.77 (0.61, 0.98), 0.67 (0.51, 0.86), and 0.53 (0.40, 0.71) (all P for trend < 0.01), respectively. This is the first study shows that increased GS is independently associated with lower prevalence of NAFLD.
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DOI：
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发表时间：
2012-02-01
影响因子：
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作者：
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