Anorexia Nervosa during Adolescence Is Associated with Decreased Gray Matter Volume in the Inferior Frontal Gyrus.
Anorexia Nervosa during Adolescence Is Associated with Decreased Gray Matter Volume in the Inferior Frontal Gyrus.
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DOI：
10.1371/journal.pone.0128548
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Tomoda A
中科院分区：
文献类型：
--
作者：
Fujisawa TX;Yatsuga C;Mabe H;Yamada E;Masuda M;Tomoda A
神经性厌食症（AN）是一种饮食失调，其特征是不懈地追求减肥，主要是通过自我饥饿和扭曲的身体形象。AN倾向于开始于女性的青春期。然而，与AN相关的潜在神经机制仍不清楚。使用基于磁共振成像扫描的基于体素的形态测定法，我们研究了AN的存在是否与脑形态学的可辨别变化相关。参与者是20名未服药的右利手早发性AN患者和14名健康对照组。使用高分辨率、T1加权、体积磁共振成像数据集（3 T Trio扫描仪; Siemens AG）评估灰质体积（GMV）的组间差异，并在控制年龄和总GMV后进行分析，AN患者的双侧额下回（IFG）减少（左侧IFG：FWE校正，p < 0.05;右侧IFG：未校正，p < 0.05）。双侧IFG的GMV与当前年龄显著相关（左侧IFG：r = -.481，p < .05;右侧IFG：r = -.601，p < .01），仅限于AN组。我们推测，IFG量减少可能会导致执行功能或神经奖励系统内的抑制控制的赤字。在这个特殊的区域内过早或不平衡的神经修剪可能是AN发病的重要因素。
Anorexia nervosa (AN) is an eating disorder characterized by the relentless pursuit to lose weight, mostly through self-starvation, and a distorted body image. AN tends to begin during adolescence among women. However, the underlying neural mechanisms related to AN remain unclear. Using voxel-based morphometry based on magnetic resonance imaging scans, we investigated whether the presence of AN was associated with discernible changes in brain morphology. Participants were 20 un-medicated, right-handed patients with early-onset AN and 14 healthy control subjects. Group differences in gray matter volume (GMV) were assessed using high-resolution, T1-weighted, volumetric magnetic resonance imaging datasets (3T Trio scanner; Siemens AG) and analyzed after controlling for age and total GMV, which was decreased in the bilateral inferior frontal gyrus (IFG) (left IFG: FWE corrected, p < 0.05; right IFG: uncorrected, p < 0.05) of patients with AN. The GMV in the bilateral IFG correlated significantly with current age (left IFG: r = -.481, p < .05; right IFG: r = -.601, p < .01) and was limited to the AN group. We speculate that decreased IFG volume might lead to deficits in executive functioning or inhibitory control within neural reward systems. Precocious or unbalanced neurological trimming within this particular region might be an important factor for the pathogenesis of AN onset.
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影响因子：
5.7
作者：
Hayasaka, S;Phan, KL;Nichols, TE
通讯作者：
Nichols, TE
DOI：
10.1007/s00406-004-0488-z
发表时间：
2004-08-01
影响因子：
4.7
作者：
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影响因子：
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作者：
Frank, GK;Bailer, UF;Kaye, WH
通讯作者：
Kaye, WH
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4.4
作者：
Brooks SJ;Barker GJ;O'Daly OG;Brammer M;Williams SC;Benedict C;Schiöth HB;Treasure J;Campbell IC
通讯作者：
Campbell IC
影响因子：
8
作者：
Campbell, Kenisha;Peebles, Rebecka
通讯作者：
Peebles, Rebecka