Pandemic potential of highly pathogenic avian influenza clade 2.3.4.4 A(H5) viruses.
Pandemic potential of highly pathogenic avian influenza clade 2.3.4.4 A(H5) viruses.
复制标题
高度致病的禽流感附枝2.3.4.4 A（H5）病毒的大流行潜力。
DOI：
10.1002/rmv.2099
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发表时间：
2020-05
影响因子：
11.1
通讯作者：
Zhang, Wenqing
中科院分区：
文献类型：
--
作者：
Yamaji, Reina;Saad, Magdi D.;Davis, Charles T.;Swayne, David E.;Wang, Dayan;Wong, Frank Y. K.;McCauley, John W.;Peiris, J. S. Malik;Webby, Richard J.;Fouchier, Ron A. M.;Kawaoka, Yoshihiro;Zhang, Wenqing
由A/鹅/广东/1/96谱系高致病性禽流感(HPAI) A(H5)病毒引起的大流行，自1996年以来已发生多波。从2013年起，进化枝2.3.4.4亚型A(H5N2)、A(H5N6)和A(H5N8)病毒的出现，在禽类中引起前所未有的大流行，并伴有严重的流行病。给世界各地家禽业带来损失。分支 2.3.4.4 A(H5) 病毒可能通过长距离候鸟传播到几个大陆以及通过邻国之间的家禽贸易，以不同的地理和进化途径进行扩张。再加上区域性的传播，病毒通过与当地病毒的重配而进一步进化。截至 2019 年 2 月，已有 23 例人类感染 2.3.4.4 H5N6 病毒，其中 16 例（70%）死亡。迄今为止，还没有 HPAI A(H5) 病毒引起可持续的人际传播。然而，由于人类缺乏群体免疫力以及病毒的不断进化，如果进化枝 2.3.4.4 A(H5) 病毒获得了在人类之间有效传播的能力，则可能存在导致流感大流行的持续风险。因此，动物、环境和公共卫生部门之间的多部门合作对于进行风险评估和制定预防疾病和控制传播的对策至关重要。在本文中，我们描述了对进化枝 2.3.4.4 A(H5) 病毒获得人际传播能力的可能性以及发生这种人际传播对人类健康影响的评估。这种结构化分析评估了病毒的特性、人群的属性以及这些病毒在动物宿主中的生态学和流行病学。
The panzootic caused by A/goose/Guangdong/1/96‐lineage highly pathogenic avian influenza (HPAI) A(H5) viruses has occurred in multiple waves since 1996. From 2013 onwards, clade 2.3.4.4 viruses of subtypes A(H5N2), A(H5N6), and A(H5N8) emerged to cause panzootic waves of unprecedented magnitude among avian species accompanied by severe losses to the poultry industry around the world. Clade 2.3.4.4 A(H5) viruses have expanded in distinct geographical and evolutionary pathways likely via long distance migratory bird dispersal onto several continents and by poultry trade among neighboring countries. Coupled with regional circulation, the viruses have evolved further by reassorting with local viruses. As of February 2019, there have been 23 cases of humans infected with clade 2.3.4.4 H5N6 viruses, 16 (70%) of which had fatal outcomes. To date, no HPAI A(H5) virus has caused sustainable human‐to‐human transmission. However, due to the lack of population immunity in humans and ongoing evolution of the virus, there is a continuing risk that clade 2.3.4.4 A(H5) viruses could cause an influenza pandemic if the ability to transmit efficiently among humans was gained. Therefore, multisectoral collaborations among the animal, environmental, and public health sectors are essential to conduct risk assessments and develop countermeasures to prevent disease and to control spread. In this article, we describe an assessment of the likelihood of clade 2.3.4.4 A(H5) viruses gaining human‐to‐human transmissibility and impact on human health should such human‐to‐human transmission occur. This structured analysis assessed properties of the virus, attributes of the human population, and ecology and epidemiology of these viruses in animal hosts.
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影响因子：
11.8
作者：
Beerens N;Heutink R;Bergervoet SA;Harders F;Bossers A;Koch G
通讯作者：
Koch G
影响因子：
4.6
作者：
Bevins SN;Dusek RJ;White CL;Gidlewski T;Bodenstein B;Mansfield KG;DeBruyn P;Kraege D;Rowan E;Gillin C;Thomas B;Chandler S;Baroch J;Schmit B;Grady MJ;Miller RS;Drew ML;Stopak S;Zscheile B;Bennett J;Sengl J;Brady C;Ip HS;Spackman E;Killian ML;Torchetti MK;Sleeman JM;Deliberto TJ
通讯作者：
Deliberto TJ
影响因子：
13.2
作者：
Fang, Shisong;Bai, Tian;Yang, Lei;Wang, Xin;Peng, Bo;Liu, Hui;Geng, Yijie;Zhang, Renli;Ma, Hanwu;Zhu, Wenfei;Wang, Dayan;Cheng, Jinquan;Shu, Yuelong
通讯作者：
Shu, Yuelong
影响因子：
3.7
作者：
Chen LM;Blixt O;Stevens J;Lipatov AS;Davis CT;Collins BE;Cox NJ;Paulson JC;Donis RO
通讯作者：
Donis RO
影响因子：
4.6
作者：
Freidl GS;van den Ham HJ;Boni MF;de Bruin E;Koopmans MP
通讯作者：
Koopmans MP