Reassessment of the Hispanic Disparity: Hepatic Steatosis Is More Prevalent in Mexican Americans Than Other Hispanics.
Reassessment of the Hispanic Disparity: Hepatic Steatosis Is More Prevalent in Mexican Americans Than Other Hispanics.
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DOI：
10.1002/hep4.1775
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发表时间：
2021-12
影响因子：
5.1
通讯作者：
Friedman TC
中科院分区：
文献类型：
--
作者：
Shaheen M;Pan D;Schrode KM;Kermah D;Puri V;Zarrinpar A;Elisha D;Najjar SM;Friedman TC
肝脂肪变性（HS）是一个日益严重的问题，在世界范围内的成年人，与种族/民族的患病率差异。本研究的目的是描述墨西哥裔美国人和其他西班牙裔美国人与其他种族/族裔人群相比，HS分期（正常/轻度[0/S1]，中度[S2]和重度[S3]）的种族/族裔患病率。我们分析了新发布的2017 - 2018年全国健康与营养检查调查中5492名12岁及以上个体的数据，这是美国成年人口的代表性样本。通过纤维扫描诊断HS，控制衰减参数值：0，<238；S1, 238还是259;S2, 260还是290;S3, > 290。我们使用双变量卡方检验和多项回归分析数据。总体HS患病率为46.9% （S2,16.6%; S3, 30.3%）。S3患病率最高的是墨西哥裔美国人（42.8%），最低的是黑人（21.6%），其他西班牙裔为27.6%，白人为30.6% （P < 0.05）。墨西哥裔美国人拥有S2和S3的可能性大约是白人的2倍，而其他西班牙裔美国人与白人没有差异。在调整后的模型中，S2和S3的常见危险因素为男性、年龄较大、高腰臀比、体重指数≥25和高甘油三酯（P < 0.05）。其他S3的危险因素是血红蛋白A1c≥5.7和高敏感C反应蛋白≥10 mg/dL （P < 0.05）。结论：我们的研究挑战了西班牙裔人群HS总体较高的范式；相反，我们的数据显示，HS在墨西哥裔美国人中高于非墨西哥裔美国人。肝脂肪变性是一种日益增长的全球性流行病，长期以来，人们一直认为西班牙裔人患肝脂肪变性的风险高于其他种族/民族。然而，以前的研究往往没有考虑到西班牙裔的不同种族起源。我们的研究表明，特别是墨西哥裔西班牙人患肝脂肪变性的风险增加，而非墨西哥裔西班牙人则没有。
Hepatic steatosis (HS) is a growing problem in adults worldwide, with racial/ethnic disparity in the prevalence of the disease. The purpose of this study was to characterize the racial/ethnic prevalence of the stages (normal/mild [S0/S1], moderate [S2], and severe [S3]) of HS in Mexican Americans and other Hispanics compared to other racial/ethnic groups. We analyzed data for 5,492 individuals 12 years and older from the newly released National Health and Nutrition Examination Survey 2017‐2018, which is a representative sample of the US adult population. HS was diagnosed by FibroScan using controlled attenuation parameter values: S0, <238; S1, 238‐259; S2, 260‐290; S3, >290. We analyzed the data using the bivariate chi‐squared test and multinomial regression. The prevalence of HS overall was 46.9% (S2,16.6%; S3, 30.3%). The prevalence of S3 was highest among Mexican Americans (42.8%), lowest among Blacks (21.6%), 27.6% in other Hispanics, and 30.6% in Whites (P < 0.05). Mexican Americans were about 2 times more likely than Whites to have S2 and S3, while other Hispanics showed no difference from Whites. In an adjusted model, the common risk factors of S2 and S3 were male sex, older ages, high waist‐to‐hip ratio, body mass index ≥25, and high triglycerides (P < 0.05). Other risk factors for S3 were hemoglobin A1c ≥5.7 and highly sensitive C‐reactive protein ≥10 mg/dL (P < 0.05). Conclusion: Our study challenges the paradigm that HS is higher in Hispanics overall; rather, our data show that HS is higher in Mexican Americans and not non‐Mexican American Hispanics. Hepatic steatosis is a growing global epidemic that it has long been thought that Hispanics are at higher risk for hepatic steatosis than other racial/ethnic groups.However, previous studies have often not taken the diverse ethnic origins of Hispanics into account.Our study shows that particularly Hispanics of Mexican descent are at increased risk for hepatic steatosis, while Hispanics of non‐Mexican descent are not.
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影响因子：
4.3
作者：
Fleischman, Michael Wayne;Budoff, Matthew;Foster, Temitope
通讯作者：
Foster, Temitope
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6.7
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