Differences of protein expression profiles, KRAS and BRAF mutation, and prognosis in right-sided colon, left-sided colon and rectal cancer.
Differences of protein expression profiles, KRAS and BRAF mutation, and prognosis in right-sided colon, left-sided colon and rectal cancer.
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右半结肠癌、左半结肠癌和直肠癌蛋白表达谱差异、KRAS和BRAF突变及预后
DOI：
10.1038/s41598-017-08413-z
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发表时间：
2017-08-11
影响因子：
4.6
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Gao XH;Yu GY;Gong HF;Liu LJ;Xu Y;Hao LQ;Liu P;Liu ZH;Bai CG;Zhang W
为了比较右侧结肠癌（RSCC）、左侧结肠癌（LSCC）和直肠癌患者的蛋白表达水平、基因突变和生存率，回顾性分析了57例右侧结肠癌、87例左侧结肠癌和145例直肠癌患者。结果表明，RSCC、LSCC和直肠癌在肿瘤直径、分化、浸润深度和TNM分期方面存在显著差异。三组间MLH1、MSH2、MSH6、PMS2、β-微管蛋白III、P53、Ki67、TOPIIα的表达水平及KRAS、BRAF基因突变均无显著差异。RSCC的无进展生存期（PFS）明显低于LRCC和直肠癌。在单因素分析中，RSCC、术前放化疗、分化差、TNM分期、血清CEA和CA19-9水平升高、肿瘤沉积、周围神经和血管侵犯是缩短PFS的预测因素。在多变量分析中，只有分化和TNM分期被发现是PFS的独立预测因子。综上所述，与LSCC和直肠癌相比，RSCC肿瘤体积较大，分化差，TNM分期较晚，生存期较短。RSCC较短的生存期可能与其固有的近端结肠位置特征导致的肿瘤分期较晚有关，而非遗传差异。
To compare protein expression levels, gene mutation and survival among Right-Sided Colon Cancer (RSCC), Left-Sided Colon Cancer (LSCC) and rectal cancer patients, 57 cases of RSCC, 87 LSCC and 145 rectal cancer patients were included retrospectively. Our results demonstrated significant differences existed among RSCC, LSCC and rectal cancer regarding tumor diameter, differentiation, invasion depth and TNM stage. No significant difference was identified in expression levels of MLH1, MSH2, MSH6, PMS2, β-Tubulin III, P53, Ki67 and TOPIIα, and gene mutation of KRAS and BRAF among three groups. Progression Free Survival (PFS) of RSCC was significantly lower than that of LRCC and rectal cancer. In univariate analyses, RSCC, preoperative chemoradiotherapy, poor differentiation, advanced TNM stage, elevated serum CEA and CA19-9 level, tumor deposit, perineural and vascular invasion were found to be predictive factors of shorter PFS. In multivariate analyses, only differentiation and TNM stages were found to be independent predictors of PFS. In conclusion, compared with LSCC and rectal cancer, RSCC has larger tumor size, poor differentiation, advanced TNM stage and shorter survival. The shorter survival in RSCC might be attributed to the advanced tumor stage caused by its inherent position feature of proximal colon rather than genetic difference.
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影响因子：
--
作者：
Paluszkiewicz, P;Berbec, H;Paszkowska, A
通讯作者：
Paszkowska, A
影响因子：
3.7
作者：
Lee YC;Lee YL;Chuang JP;Lee JC
通讯作者：
Lee JC
影响因子：
11.5
作者：
Frattini, M;Balestra, D;Pierotti, MA
通讯作者：
Pierotti, MA
影响因子：
5.2
作者：
Minoo, P.;Zlobec, I.;Lugli, A.
通讯作者：
Lugli, A.
影响因子：
3.4
作者：
Melling, Nathaniel;Kowitz, Charlotte Marie;Marx, Andreas Holger
通讯作者：
Marx, Andreas Holger