Effects of weight loss and exercise on apelin serum concentrations and adipose tissue expression in human obesity.
Effects of weight loss and exercise on apelin serum concentrations and adipose tissue expression in human obesity.
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DOI：
10.1159/000348667
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发表时间：
2013
期刊：
影响因子：
3.6
通讯作者：
Blüher M
中科院分区：
文献类型：
--
作者：
Krist J;Wieder K;Klöting N;Oberbach A;Kralisch S;Wiesner T;Schön MR;Gärtner D;Dietrich A;Shang E;Lohmann T;Dreßler M;Fasshauer M;Stumvoll M;Blüher M
Apelin 是一种脂肪因子，在调节葡萄糖稳态中发挥作用，并可能有助于增加脂肪组织量与肥胖相关代谢疾病之间的联系。在这里，我们研究了大网膜和皮下 (SC) 脂肪组织 apelin 及其受体 APJ mRNA 表达在人类肥胖中的作用，并在三项减肥干预研究中检验循环 apelin 的变化与脂肪量减少相关的假设。在一项横断面研究 (n = 629) 中测量了 740 名个体的 Apelin 血清浓度，其中包括分析了网膜和 SC apelin mRNA 表达的亚组 (n = 161)，并采用三种干预措施：12 周运动 (n = 60)、6 个月热量限制饮食 (n = 19)、减肥手术后 12 个月 (n = 32)。 Apelin mRNA 在 2 型糖尿病患者的脂肪组织中表达显着较高，并且与循环 apelin、BMI、体脂、C 反应蛋白和胰岛素敏感性相关。肥胖手术引起的体重减轻导致网膜和 SC apelin 表达显着减少。所有干预措施均导致 apelin 血清浓度显着降低，这与胰岛素敏感性的改善显着相关，与 BMI 的变化无关。减少apelin表达和血清浓度可能有助于改善胰岛素敏感性，而不仅仅是显着减轻体重。
Apelin is an adipokine which plays a role in the regulation of glucose homeostasis and may contribute to the link between increased adipose tissue mass and obesity related metabolic diseases. Here we investigate the role of omental and subcutaneous (SC) adipose tissue apelin and its receptor APJ mRNA expression in human obesity and test the hypothesis that changes in circulating apelin are associated with reduced fat mass in three weight loss intervention studies. Apelin serum concentration was measured in 740 individuals in a cross-sectional (n = 629) study including a subgroup (n = 161) for which omental and SC apelin mRNA expression has been analyzed and in three interventions: 12 weeks exercise (n = 60), 6 months calorie-restricted diet (n = 19), 12 months after bariatric surgery (n = 32). Apelin mRNA is significantly higher expressed in adipose tissue of patients with type 2 diabetes and correlates with circulating apelin, BMI, body fat, C-reactive protein, and insulin sensitivity. Obesity surgery-induced weight loss causes a significant reduction in omental and SC apelin expression. All interventions led to significantly reduced apelin serum concentrations which significantly correlate with improved insulin sensitivity, independently of changes in BMI. Reduced apelin expression and serum concentration may contribute to improved insulin sensitivity beyond significant weight loss.
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DOI：
10.1016/j.numecd.2008.12.008
发表时间：
2009-11-01
影响因子：
3.9
作者：
Heinonen, M. V.;Laaksonen, D. E.;Herzig, K. H.
通讯作者：
Herzig, K. H.
DOI：
10.1006/bbrc.1998.9489
发表时间：
1998-10-20
影响因子：
3.1
作者：
Tatemoto, K;Hosoya, M;Fujino, M
通讯作者：
Fujino, M
影响因子：
16.2
作者：
Blueher, Matthias;Williams, Catherine J.;Mantzoros, Christos S.
通讯作者：
Mantzoros, Christos S.
影响因子：
20.1
作者：
Kuba, Keiji;Zhang, Liyong;Penninger, Josef M.
通讯作者：
Penninger, Josef M.
影响因子：
9.8
作者：
Reinehr, Thomas;Woelfle, Joachim;Roth, Christian L.
通讯作者：
Roth, Christian L.