Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population.
Increased plasma levels of lncRNA H19 and LIPCAR are associated with increased risk of coronary artery disease in a Chinese population.
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lncRNA H19 和 LIPCAR 血浆水平升高与中国人群冠心病风险增加相关
DOI：
10.1038/s41598-017-07611-z
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发表时间：
2017-08-08
影响因子：
4.6
通讯作者：
Wang LS
中科院分区：
文献类型：
--
作者：
Zhang Z;Gao W;Long QQ;Zhang J;Li YF;Liu DC;Yan JJ;Yang ZJ;Wang LS
最近对动物模型和人类的研究表明，长链非编码 RNA (lncRNA) 参与动脉粥样硬化的发生，从而形成冠状动脉疾病 (CAD) 的病理基础。血浆和血清中的 LncRNA 被认为是心血管疾病（尤其是 CAD）诊断和预后的有前景的新型生物标志物。我们使用定量实时逆转录聚合酶链反应（qRT-PCR）方法测量了 300 名 CAD 患者和 180 名对照受试者血浆样本中已知与动脉粥样硬化相关的 8 种 lncRNA 的循环水平。我们发现 CAD 患者血浆中 H19 和预测心脏重塑的长基因间非编码 RNA (LIPCAR) 水平显着升高。 H19 的受试者工作特征曲线下面积为 0.631，LIPCAR 的受试者工作特征曲线下面积为 0.722。多变量逻辑回归分析表明，即使在调整传统心血管危险因素后，血浆 H19 和 LIPCAR 也是 CAD 的独立预测因子。进一步的研究发现，与心功能正常的 CAD 患者相比，患有心力衰竭的 CAD 患者血浆中 H19 和 LIPCAR 的水平也有所升高。综上所述，我们的结果表明 H19 和 LIPCAR 血浆水平升高与 CAD 风险增加相关，可被视为 CAD 的新型生物标志物。
Recent studies in animal models and humans show that long non-coding RNAs (lncRNAs) are involved in the development of atherosclerosis, which contributes to the pathological foundation of coronary artery disease (CAD). LncRNAs in plasma and serum have been considered as promising novel biomarkers for diagnosis and prognosis of cardiovascular diseases, especially CAD. We here measured the circulating levels of 8 individual lncRNAs which are known to be relevant to atherosclerosis in the plasma samples from 300 patients with CAD and 180 control subjects by using quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) methods. We found that the plasma level of H19 and long intergenic non-coding RNA predicting cardiac remodeling (LIPCAR) were significantly increased in patients with CAD. The area under the receiver operating characteristic curve was 0.631 for H19 and 0.722 for LIPCAR. Multivariate logistic regression analyses indicated that plasma H19 and LIPCAR were independent predictors for CAD, even after adjustment for traditional cardiovascular risk factors. Further studies identified that plasma levels of H19 and LIPCAR were also increased in CAD patients with heart failure compared to those with normal cardiac function. Taken together, our results suggest that increased plasma levels of H19 and LIPCAR are associated with increased risk of CAD and may be considered as novel biomarkers for CAD.
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影响因子：
--
作者：
Novák J;Olejníčková V;Tkáčová N;Santulli G
通讯作者：
Santulli G
影响因子：
7.4
作者：
Greco S;Zaccagnini G;Perfetti A;Fuschi P;Valaperta R;Voellenkle C;Castelvecchio S;Gaetano C;Finato N;Beltrami AP;Menicanti L;Martelli F
通讯作者：
Martelli F
DOI：
10.1126/science.1240925
发表时间：
2013-08-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Carpenter S;Aiello D;Atianand MK;Ricci EP;Gandhi P;Hall LL;Byron M;Monks B;Henry-Bezy M;Lawrence JB;O'Neill LA;Moore MJ;Caffrey DR;Fitzgerald KA
通讯作者：
Fitzgerald KA
影响因子：
3
作者：
Gao, Wei;Wang, Ze-Mu;Wang, Lian-Sheng
通讯作者：
Wang, Lian-Sheng
长基因间非编码 RNA p21 在血管内皮细胞中的作用
影响因子：
3.1
作者：
He, Chao;Ding, Jia-Wang;Yang, Jian
通讯作者：
Yang, Jian