An assessment of ambient noise and other environmental variables in a nonhuman primate housing facility.
An assessment of ambient noise and other environmental variables in a nonhuman primate housing facility.
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DOI：
10.1038/s41684-022-01017-9
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发表时间：
2022-08
期刊：
影响因子：
6.9
通讯作者：
中科院分区：
文献类型：
--
作者：
噪声和其他环境变量代表了动物研究的潜在混乱。与听觉研究相关的是，持续的高水平环境噪声可能会改变实验室动物的听觉灵敏度并降低其健康状况。本研究的目的是评估范德比尔特大学医学中心用于听觉研究的非人灵长类动物的环境条件。使用放置在猕猴饲养室空笼内的环境监测装置记录声级、振动、温度、湿度和亮度。每次录音持续一周，在房间内的三个不同位置进行。振动、温度、湿度和亮度均在非人灵长类动物的推荐水平范围内变化，但笼底位置的低亮度水平除外。每个笼位置的声级特征为58-62 dB声压级的低基线，瞬态峰值高达109 dB声压级。不同地点的声级差异很大，但只有1.5 dB左右。超过建议声级的瞬态峰值反映了非常低的噪声剂量，但超过了可能引起应激反应的惊吓诱导水平。根据这些发现，该灵长类动物设施的饲养室中的环境噪音水平在可接受的水平范围内，不太可能导致非人类灵长类动物的听力障碍。我们的研究结果建立了灵长类动物设施环境条件的规范值，可用于为非人类灵长类动物研究和护理提供最佳实践信息，并为未来的衰老和慢性噪声暴露研究提供基线。
Acoustic noise and other environmental variables represent potential confounds for animal research. Of relevance to auditory research, sustained high levels of ambient noise may modify hearing sensitivity and decrease well-being among laboratory animals. The present study was conducted to assess environmental conditions in an animal facility that houses nonhuman primates used for auditory research at the Vanderbilt University Medical Center. Sound levels, vibration, temperature, humidity and luminance were recorded using an environmental monitoring device placed inside of an empty cage in a macaque housing room. Recordings lasted 1 week each, at three different locations within the room. Vibration, temperature, humidity and luminance all varied within recommended levels for nonhuman primates, with one exception of low luminance levels in the bottom cage location. Sound levels at each cage location were characterized by a low baseline of 58-62 dB sound pressure level, with transient peaks up to 109 dB sound pressure level. Sound levels differed significantly across locations, but only by about 1.5 dB. The transient peaks beyond recommended sound levels reflected a very low noise dose, but exceeded startle-inducing levels, which could elicit stress responses. Based on these findings, ambient noise levels in the housing rooms in this primate facility are within acceptable levels and unlikely to contribute to hearing deficits in the nonhuman primates. Our results establish normative values for environmental conditions in a primate facility, can be used to inform best practices for nonhuman primate research and care, and form a baseline for future studies of aging and chronic noise exposure.
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影响因子：
2.8
作者：
Mackey CA;McCrate J;MacDonald KS;Feller J;Liberman L;Liberman MC;Hackett TA;Ramachandran R
通讯作者：
Ramachandran R
影响因子：
2.8
作者：
Burton JA;Mackey CA;MacDonald KS;Hackett TA;Ramachandran R
通讯作者：
Ramachandran R
影响因子：
6.9
作者：
Lauer, Amanda M.;May, Bradford J.;Watson, Julie
通讯作者：
Watson, Julie
DOI：
10.1007/s10162-014-0467-7
发表时间：
2014-10-01
影响因子：
2.4
作者：
Bohlen, Peter;Dylla, Margit;Ramachandran, Ramnarayan
通讯作者：
Ramachandran, Ramnarayan
DOI：
10.1523/jneurosci.2845-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kujawa SG;Liberman MC
通讯作者：
Liberman MC