Metabolic reservoir cycles in cancer.
Metabolic reservoir cycles in cancer.
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DOI：
10.1016/j.semcancer.2022.03.023
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发表时间：
2022-11
影响因子：
14.5
通讯作者：
Le, Anne
中科院分区：
文献类型：
--
作者：
Zhang, Cissy;Quinones, Addison;Le, Anne
关键词：
癌细胞具有各种生物学过程，以确保即使在缺氧、营养缺乏和氧化应激等不利条件下也能存活和增殖。癌细胞的定义特征之一是它们能够重新编程新陈代谢以满足其需求。基于癌症代谢领域十多年的研究，许多独特的代谢能力在今天仍在被发现。迄今为止，在癌症代谢领域中的一个最新发现是癌细胞以可以容易地转化为葡萄糖和谷氨酰胺以供以后使用的形式储存重要代谢物的能力。我们称这些形式为“代谢库”。虽然已经对储存分子如糖原、甘油三酯和磷酸肌酸（PCr）进行了许多研究，但很少有人探索癌症作为一个整体的“代谢库”的概念。在这篇综述中，我们将提供一个概述这一概念，以前已知的水库，包括糖原，甘油三酯，和PCr，和新的发现，包括新发现的水库，如N-乙酰基-乙酰基-谷氨酸（NAAG），乳酸，和γ-氨基丁酸（GABA）。我们还将讨论破坏这些储库循环是否可能是癌症治疗的新途径。
Cancer cells possess various biological processes to ensure survival and proliferation even under unfavorable conditions such as hypoxia, nutrient deprivation, and oxidative stress. One of the defining hallmarks of cancer cells is their ability to reprogram their metabolism to suit their needs. Building on over a decade of research in the field of cancer metabolism, numerous unique metabolic capabilities are still being discovered in the present day. One recent discovery in the field of cancer metabolism that was hitherto unexpected is the ability of cancer cells to store vital metabolites in forms that can be readily converted to glucose and glutamine for later use. We called these forms “metabolic reservoirs.” While many studies have been conducted on storage molecules such as glycogen, triglyceride, and phosphocreatine (PCr), few have explored the concept of “metabolic reservoirs” for cancer as a whole. In this review, we will provide an overview of this concept, the previously known reservoirs including glycogen, triglyceride, and PCr, and the new discoveries made including the newly discovered reservoirs such as N-acetyl-aspartyl-glutamate (NAAG), lactate, and γ- aminobutyric acid (GABA). We will also discuss whether disrupting these reservoir cycles may be a new avenue for cancer treatment.
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DOI：
10.1007/978-3-030-65768-0_1
发表时间：
2021-01-01
期刊：
HETEROGENEITY OF CANCER METABOLISM, 2ND EDITION
影响因子：
--
作者：
Bose, Sminu;Zhang, Cissy;Le, Anne
通讯作者：
Le, Anne
影响因子：
56.9
作者：
Das, Suman K.;Eder, Sandra;Hoefler, Gerald
通讯作者：
Hoefler, Gerald
影响因子：
9.7
作者：
KOKOGLU, E;KARAARSLAN, I;BALOGLU, H
通讯作者：
BALOGLU, H
DOI：
10.1007/978-3-030-65768-0_2
发表时间：
2021-01-01
期刊：
HETEROGENEITY OF CANCER METABOLISM, 2ND EDITION
影响因子：
--
作者：
Li, Ting;Copeland, Christopher;Le, Anne
通讯作者：
Le, Anne
细胞外代谢能量可以促进癌症的进展。
影响因子：
64.5
作者：
Loo JM;Scherl A;Nguyen A;Man FY;Weinberg E;Zeng Z;Saltz L;Paty PB;Tavazoie SF
通讯作者：
Tavazoie SF