Noradrenergic alpha-2A receptor activation suppresses courtship vocalization in male Japanese quail

Noradrenergic alpha-2A receptor activation suppresses courtship vocalization in male Japanese quail
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去甲肾上腺素能α-2A受体激活抑制雄性日本鹌鹑的求偶发声

DOI:
10.1101/2021.04.01.438152
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发表时间:
2021
期刊:
--
影响因子:
--
通讯作者:
Tobari Y
Tobari Y
中科院分区:
--
文献类型:
--
作者:
Tobari Y

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雄性日本鹌鹑在繁殖季节会发出高频的乌鸦叫声来吸引雌性。丘间核 (ICo) 是鸟类的中脑发声中心,对 ICo 的电刺激会产生包括啼叫在内的叫声。去甲肾上腺素在性行为中起着重要作用,但去甲肾上腺素在控制鹌鹑求偶发声中的作用尚未明确。使用剂量依赖性脑室内注射可乐定(一种α2-肾上腺素能受体特异性激动剂),鸡鸣声立即被抑制。在用可乐定抑制乌鸦的同时,ICo 中立即早期基因 zenk mRNA 减少;在核的背内侧分裂中没有检测到zenk mRNA表达。使用组织化学,我们确定 ICo 接受去甲肾上腺素能神经支配并表达 α2A-肾上腺素能受体 mRNA。综上所述,这些数据表明去甲肾上腺素可能通过 ICo 神经元上表达的 α2A 肾上腺素受体来调节鹌鹑的求偶发声。
Male Japanese quail produce high-frequency crow vocalizations to attract females during the breeding season. The nucleus of intercollicularis (ICo) is the midbrain vocal center in birds and electrical stimulation of the ICo produces calls that include crowing. Noradrenaline plays a significant role in sexual behavior but the contribution of noradrenaline in the control of courtship vocalizations in quail has not been well established. Using dose-dependent intracerebroventricular injection of clonidine, an α2-adrenergic receptor-specific agonist, crowing vocalization was immediately suppressed. At the same time as crow suppression by clonidine there was a reduction of immediate early gene, zenk mRNA, in the ICo; no zenk mRNA expression was detected in the dorsomedial division of the nucleus. Using histochemistry, we determined that the ICo receives noradrenergic innervation and expresses α2A-adrenergic receptor mRNA. Taken together, these data suggest that noradrenaline regulates courtship vocalization in quail, possiblyviathe α2A-adrenergic receptor expressed on ICo neurons.
交配激活雄性鹌鹑前脑中的 Fos 样免疫反应性
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