Application and progress of the detection technologies in hepatocellular carcinoma.
Application and progress of the detection technologies in hepatocellular carcinoma.
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肝细胞癌检测技术的应用及进展
DOI：
10.1016/j.gendis.2022.04.003
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发表时间：
2023-09
期刊：
影响因子：
6.8
通讯作者：
Du, Jian
中科院分区：
文献类型：
--
作者：
Yan, Qi;Sun, Yuan-song;An, Ran;Liu, Fang;Fang, Qi;Wang, Zhen;Xu, Tao;Chen, Lijian;Du, Jian
肝细胞癌具有很高的发病率和病死率，在大多数病例中，确诊时已处于晚期。因此，早期预防和发现肝细胞癌是最有效的两种策略。然而，实践指南中推荐的检测肝细胞癌的方法除了肝活检之外，不能保证高灵敏度和特异度，这被称为“金标准”。本文将肝细胞癌的检测分为治疗前诊断和治疗后监测，发现除传统的影像检查和肝活检外，甲胎蛋白(AFP)、晶状体凝集素反应部分AFP(AFP-L3)、维生素K缺乏或拮抗剂II诱导蛋白(PIVKA-II)和其他生物标志物是很好的肝细胞癌标志物，特别是当它们联合使用时。最值得注意的是，新出现的液体活检在检测肝癌方面显示出巨大的希望。此外，乳酸脱氢酶(LDH)、细胞因子信号转导抑制因子(SOCS)等相关生物标志物有望成为肝癌治疗后监测的生物标志物。通过对肝细胞癌诊断技术的详细介绍，可以对其发展过程有一个详细的了解，进而从中得到一些启示，从而提高肝细胞癌的诊断率，降低其死亡率。
Hepatocellular carcinoma (HCC) has a very high incidence and fatality rate, and in most cases, it is already at an advanced stage when diagnosed. Therefore, early prevention and detection of HCC are two of the most effective strategies. However, the methods recommended in the practice guidelines for the detection of HCC cannot guarantee high sensitivity and specificity except for the liver biopsy, which is known as the “gold standard”. In this review, we divided the detection of HCC into pre-treatment diagnosis and post-treatment monitoring, and found that in addition to the traditional imaging detection and liver biopsy, alpha fetoprotein (AFP), lens culinaris-agglutinin-reactive fraction of AFP (AFP-L3), protein induced by vitamin K absence or antagonist-II (PIVKA-II) and other biomarkers are excellent biomarkers for HCC, especially when they are combined together. Most notably, the emerging liquid biopsy shows great promise in detecting HCC. In addition, lactic dehydrogenase (LDH), suppressor of cytokine signaling (SOCS) and other relevant biomarkers may become promising biomarkers for HCC post-treatment monitoring. Through the detailed introduction of the diagnostic technology of HCC, we can have a detailed understanding of its development process and then obtain some enlightenment from the diagnosis, to improve the diagnostic rate of HCC and reduce its mortality.
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影响因子：
4
作者：
Choucair K;Kamran S;Saeed A
通讯作者：
Saeed A
影响因子：
8
作者：
Aouidat, Fatima;Boumati, Sarah;Spadavecchia, Jolanda
通讯作者：
Spadavecchia, Jolanda
DOI：
10.1016/j.ejca.2018.02.010
发表时间：
2018-05
期刊：
European journal of cancer (Oxford, England : 1990)
影响因子：
--
作者：
Chu YJ;Yang HI;Wu HC;Lee MH;Liu J;Wang LY;Lu SN;Jen CL;You SL;Santella RM;Chen CJ
通讯作者：
Chen CJ
影响因子：
8.2
作者：
通讯作者：
--
影响因子：
2.9
作者：
Hou SC;Xiao MB;Ni RZ;Ni WK;Jiang F;Li XY;Lu CH;Chen BY
通讯作者：
Chen BY