Aflatoxin B(1) exposure increases the risk of hepatocellular carcinoma associated with hepatitis C virus infection or alcohol consumption.
Aflatoxin B(1) exposure increases the risk of hepatocellular carcinoma associated with hepatitis C virus infection or alcohol consumption.
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DOI：
10.1016/j.ejca.2018.02.010
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Chen CJ
中科院分区：
文献类型：
--
作者：
Chu YJ;Yang HI;Wu HC;Lee MH;Liu J;Wang LY;Lu SN;Jen CL;You SL;Santella RM;Chen CJ
黄曲霉毒素B1(AFB1)在丙型肝炎病毒(丙型肝炎病毒)感染者和未感染乙型肝炎病毒和丙型肝炎病毒的人群(非乙非丙型)中的致癌性研究很少。这项嵌套在社区队列中的病例对照研究旨在调查丙型肝炎病毒感染者和非B-非-C参与者中与AFB1相关的肝癌风险。对100例抗-HCV和HBs Ag阴性(非B-非C)的肝细胞癌患者和1767例血清抗-HCV和HBs Ag阴性的肝细胞癌患者和176例抗-HCV血清阳性的肝细胞癌患者和176例正常对照的血清AFB1-白蛋白加合物水平进行了检测。用Logistic回归估计优势比(OR)和95%可信区间(95%CI)。在20年的随访中，在非B-非C组(p=0.0162)和丙型肝炎病毒感染组(p<；0.0001)中，血清黄曲霉毒素B-1-白蛋白加合物水平较高的参与者对新发展的肝癌的随访时间显著缩短。随访8年内，丙型肝炎病毒感染和AFB1暴露是肝细胞癌的独立危险因素。血清AFB1-白蛋白加合物水平的升高与习惯性饮酒的非B-非C参与者[高水平与低/不可检测水平的粗OR(95%CI)4.22(1.16-15.37)]和丙型肝炎病毒感染的参与者[3.39(1.31-8.77)]在8年内新发肝癌的风险增加显著相关，但在没有饮酒习惯的非B-非C参与者中不显著。在调整了其他肝细胞癌预测因素后，AFB1暴露仍然是丙型肝炎相关肝细胞癌的独立风险预测因素[多变量调整后的OR(95%CI)，3.65(1.32-10.10)]。接触黄曲霉毒素B-1会导致参与者发生肝细胞癌，这些参与者有明显的肝硬变危险因素，包括酒精和丙型肝炎病毒感染。
Hepatocarcinogenicity of Aflatoxin B1 (AFB1) has rarely been studied in populations with hepatitis C virus (HCV) infection and those without hepatitis B virus (HBV) and HCV infection (non-B-non-C). This case-control study nested in a community-based cohort aimed to investigate the HCC risk associated with AFB1 in HCV-infected and non-B-non-C participants. Baseline serum AFB1-albumin adduct levels were measured in 100 HCC cases and 1767 controls seronegative for anti-HCV and HBsAg (non-B-non-C), and another 103 HCC cases and 176 controls who were anti-HCV-seropositive and HBsAg-seronegative. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated using logistic regression. In 20 years of follow-up, the follow-up time to newly-developed HCC was significantly shorter in participants with higher serum AFB1-albumin adduct levels in non-B-non-C (p=0.0162) and HCV-infected participants (p<0.0001). Within 8 years of follow-up, HCV infection and AFB1 exposure were independent risk factors for HCC. Elevated serum AFB1-albumin adduct levels were significantly associated with an increased risk of HCC newly-developed within 8 years of follow-up in non-B-non-C participants with habitual alcohol consumption [crude OR (95% CI) for high vs. low/undetectable levels, 4.22 (1.16–15.37)] and HCV-infected participants [3.39 (1.31–8.77)], but not in non-B-non-C participants without alcohol drinking habit. AFB1 exposure remained an independent risk predictor for HCV-related HCC after adjustment for other HCC predictors [multivariate-adjusted OR (95% CI), 3.65 (1.32–10.10)]. AFB1 exposure contributes to the development of HCC in participants with significant risk factors for cirrhosis including alcohol and HCV infection.
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影响因子：
29.4
作者：
El-Serag HB
通讯作者：
El-Serag HB
影响因子：
6.4
作者：
Chu YJ;Yang HI;Wu HC;Liu J;Wang LY;Lu SN;Lee MH;Jen CL;You SL;Santella RM;Chen CJ
通讯作者：
Chen CJ
影响因子：
3.8
作者：
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通讯作者：
Groopman, John D.
影响因子：
6.4
作者：
MCMAHON, BJ;ALWARD, WLM;MAYNARD, JE
通讯作者：
MAYNARD, JE
DOI：
10.1080/19440049.2012.751630
发表时间：
2013-03-01
影响因子：
2.9
作者：
Palliyaguru, D. L.;Wu, F.
通讯作者：
Wu, F.