Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions.
Targeted peripheral focused ultrasound stimulation attenuates obesity-induced metabolic and inflammatory dysfunctions.
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DOI：
10.1038/s41598-021-84330-6
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发表时间：
2021-03-03
影响因子：
4.6
通讯作者：
Chavan SS
中科院分区：
文献类型：
--
作者：
Huerta TS;Devarajan A;Tsaava T;Rishi A;Cotero V;Puleo C;Ashe J;Coleman TR;Chang EH;Tracey KJ;Chavan SS
肥胖是一个日益严重的健康问题，与发病率和死亡率的风险增加有关。慢性低度炎症与肥胖引起的代谢并发症有关。外周聚焦超声刺激(PFUS)是一种新兴的非侵入性炎症调控技术。在这里，我们推断，聚焦超声刺激肝脏可能会减轻肥胖相关的炎症和其他合并症。在高脂高碳水化合物“西方”饮食8周后，C57BL/6J小鼠接受假刺激或聚焦超声刺激肝门。每天聚焦肝脏的超声刺激8周显著降低体重，循环血脂，并缓解脂肪因子的失调。此外，聚焦肝脏的超声刺激显著降低了肝脏细胞因子水平和白细胞浸润。我们的研究结果证明了肝脏聚焦超声在减轻小鼠肥胖和肥胖相关并发症方面的有效性。这些发现表明，肝脏聚焦超声作为一种可能的新型非侵入性方法在肥胖症的治疗中具有以前未被认识到的潜力。
Obesity, a growing health concern, is associated with an increased risk of morbidity and mortality. Chronic low-grade inflammation is implicated in obesity-driven metabolic complications. Peripheral focused ultrasound stimulation (pFUS) is an emerging non-invasive technology that modulates inflammation. Here, we reasoned that focused ultrasound stimulation of the liver may alleviate obesity-related inflammation and other comorbidities. After 8 weeks on a high-fat high-carbohydrate “Western” diet, C57BL/6J mice were subjected to either sham stimulation or focused ultrasound stimulation at the porta hepatis. Daily liver-focused ultrasound stimulation for 8 weeks significantly decreased body weight, circulating lipids and mitigated dysregulation of adipokines. In addition, liver-focused ultrasound stimulation significantly reduced hepatic cytokine levels and leukocyte infiltration. Our findings demonstrate the efficacy of hepatic focused ultrasound for alleviating obesity and obesity-associated complications in mice. These findings suggest a previously unrecognized potential of hepatic focused ultrasound as a possible novel noninvasive approach in the context of obesity.
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