The nucleus retroambiguus as possible site for inspiratory rhythm generation caudal to obex.
The nucleus retroambiguus as possible site for inspiratory rhythm generation caudal to obex.
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DOI：
10.1016/j.resp.2011.12.007
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发表时间：
2012-03-15
影响因子：
2.3
通讯作者：
Dutschmann, Mathias
中科院分区：
文献类型：
--
作者：
Jones, Sarah E.;Saad, Mona;Lewis, David I.;Subramanian, Hari H.;Dutschmann, Mathias
我们研究了脊椎动物是否能产生吸气节律。在大鼠脑干灌流标本上记录了脊髓吸气性膈神经（PNA）和颅吸气性舌下神经（HNA）的活动。在枕骨尾侧1.5 mm（锥体交叉）或2 mm（第一颈椎节段）处进行完全横断。兴奋性驱动增强细胞外钾，高碳酸血症或刺激动脉化学感受器。尾部横断立即消除了PNA的下行网络驱动，而头部吸气HNA保持不受影响。横断后，PNA爆发仍然零星，即使在增强兴奋性驱动。这意味着，颈椎回路缺乏内在的节律能力。喙部横断也立即废除PNA。然而，海航也逐渐失去了它的振幅和节奏。化学感受器激活仅触发紧张性、非节律性HNA。因此，桥脑-延髓回路的完整性得以维持。我们的研究结果表明，重叠尾侧核的区域提供了关键的上升输入脑桥延髓呼吸网络的吸气节律的产生。
We investigated whether spinalized animals can produce inspiratory rhythm. We recorded spinal inspiratory phrenic (PNA) and cranial inspiratory hypoglossal (HNA) nerve activity in the perfused brainstem preparation of rat. Complete transverse transections were performed at 1.5 (pyramidal decussation) or 2 mm (first cervical spinal segment) caudal to obex. Excitatory drive was enhanced by either extracellular potassium, hypercapnia or by stimulating arterial chemoreceptors. Caudal transections immediately eliminated descending network drive for PNA, while the cranial inspiratory HNA remained unaffected. After transection, PNA bursting remained sporadic even during enhanced excitatory drive. This implies, cervical spinal circuits lack intrinsic rhythmogenic capacity. Rostral transections also abolished PNA immediately. However, HNA also progressively lost its amplitude and rhythm. Chemoreceptor activation only triggered tonic, non-rhythmic HNA. Thus the integrity of ponto-medullary circuitry was maintained. Our results suggest that an area overlapping the caudal nucleus retroambiguus provides critical ascending input to the ponto-medullary respiratory network for inspiratory rhythm generation.
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