Serological evidence of hantavirus infection in apparently healthy people from rural and slum communities in southern Chile.
Serological evidence of hantavirus infection in apparently healthy people from rural and slum communities in southern Chile.
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DOI：
10.3390/v7042006
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发表时间：
2015-04-17
期刊：
影响因子：
--
通讯作者：
Padula P
中科院分区：
文献类型：
--
作者：
Muñoz-Zanzi C;Saavedra F;Otth C;Domancich L;Hott M;Padula P
汉坦病毒病在美国是公认的，因为它在临床病例中进展迅速，发生在以前健康的年轻人中，并且病死率很高。汉坦病毒病现在被提出用来定义临床表现的多样性。自1995年以来，智利共报告了902例由安第斯病毒(ANDV)引起的汉坦病毒肺综合征病例，总死亡率为32%。这份报告描述了智利南部农村和城市贫民窟中表面健康的人中汉坦病毒的血清流行病学。934份样本中有10份阳性结果，血清阳性率为1.07%(95%可信区间：0.05%-2.0%)。来自农村和贫民窟的个人(1.3%)和贫民窟(1.5%)的阳性样本比例高于农场(0.5%)。血清阳性与年龄(p=0.011)、低教育水平(p=0.006)和与家庭相关的职业(家庭主妇、退休或学生)(p=0.016)有关。在被困在周边环境中的38只乙形虫啮齿动物中，没有发现感染的证据。我们的发现突出表明，暴露风险与记录较少的风险因素有关，例如贫民窟和农村的妇女，以及可能表现为不需要医疗护理或被误诊的流感样疾病的感染的发生。
Hantavirus disease in America has been recognizable because of its rapid progression in clinical cases, occurrence in previously healthy young adults, and high case fatality rate. Hantavirus disease has been proposed now to define the diversity of clinical manifestations. Since 1995, a total of 902 cases of hantavirus pulmonary syndrome have been reported in Chile, caused by Andes virus (ANDV), with overall fatality of 32%. This report describes the sero-epidemiology of hantavirus in apparently healthy people in rural and urban slum communities from southern Chile. Ten of 934 samples yielded a positive result resulting in a seroprevalence of 1.07% (95% confidence intervals: 0.05%–2.0%). A higher proportion of positive samples was found among individuals from rural villages (1.3%) and slums (1.5%) compared with farms (0.5%). Seropositivity was associated with age (p = 0.011), low education level (p = 0.006) and occupations linked to the household (homemaker, retired, or student) (p = 0.016). No evidence of infection was found in 38 sigmodontinae rodents trapped in the peri-domestic environment. Our findings highlight that exposure risk was associated with less documented risk factors, such as women in slum and rural villages, and the occurrence of infection that may have presented as flu-like illness that did not require medical attention or was misdiagnosed.
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影响因子：
5
作者：
Clement, Jan;Maes, Piet;Van Ranst, Marc
通讯作者：
Van Ranst, Marc
DOI：
10.4269/ajtmh.1998.59.438
发表时间：
1998-09-01
影响因子：
3.3
作者：
Ferrer, JF;Jonsson, CB;Hjelle, B
通讯作者：
Hjelle, B
影响因子：
5
作者：
Moraes Figueiredo, Luiz Tadeu;de Souza, William Marciel;Alcira Enria, Delia
通讯作者：
Alcira Enria, Delia
影响因子：
--
作者：
Rivas, YJ;Moros, Z;Ludert, JE
通讯作者：
Ludert, JE
DOI：
10.3390/v6052214
发表时间：
2014-05-26
期刊：
Viruses
影响因子：
--
作者：
Charbonnel N;Pagès M;Sironen T;Henttonen H;Vapalahti O;Mustonen J;Vaheri A
通讯作者：
Vaheri A