Nutrition and microRNAs: Novel Insights to Fight Sarcopenia.
Nutrition and microRNAs: Novel Insights to Fight Sarcopenia.
复制标题
营养和microrna：对抗肌肉减少症的新见解。
DOI：
10.3390/antiox9100951
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发表时间：
2020-10-02
期刊：
影响因子：
--
通讯作者：
Scicchitano BM
中科院分区：
文献类型：
--
作者：
Barbiera A;Pelosi L;Sica G;Scicchitano BM
骨质疏松症是一种与年龄相关的骨骼肌质量和力量的进行性丧失，可能会导致身体虚弱程度增加，并增加不良事件的风险。低度全身炎症、肌肉蛋白稳态丧失、线粒体功能障碍、卫星细胞数量和功能减少似乎是导致肌肉萎缩的关键因素，这可能是导致骨骼肌减少的病理生理机制之一。虽然据报道，一系列遗传、激素和环境因素导致了石棺减少症的发生，但针对蛋白质或抗氧化剂摄入的饮食干预可能在增加肌肉质量和力量、调节蛋白质动态平衡、氧化反应和细胞自噬方面具有积极效果，从而延长细胞寿命。MicroRNAs(MiRNAs)是一种内源性的非编码小RNA，控制着不同组织中基因的表达。在骨骼肌中，一系列的miRNAs被称为myomiRNAs，参与许多生理过程，如生长、发育以及肌肉质量和功能的维持。本综述旨在介绍和讨论与石棺减少症的病理生理效应有关的一些最相关的分子机制。此外，我们还探讨了营养作为一种可能的方式来对抗与衰老相关的肌肉质量和功能丧失的作用，并特别关注了营养依赖的miRNAs调节。这一综述将为更好地了解石棺减少症提供重要信息，从而促进对抗衰老的病理生理效应的研究和治疗策略。
Sarcopenia is a progressive age-related loss of skeletal muscle mass and strength, which may result in increased physical frailty and a higher risk of adverse events. Low-grade systemic inflammation, loss of muscle protein homeostasis, mitochondrial dysfunction, and reduced number and function of satellite cells seem to be the key points for the induction of muscle wasting, contributing to the pathophysiological mechanisms of sarcopenia. While a range of genetic, hormonal, and environmental factors has been reported to contribute to the onset of sarcopenia, dietary interventions targeting protein or antioxidant intake may have a positive effect in increasing muscle mass and strength, regulating protein homeostasis, oxidative reaction, and cell autophagy, thus providing a cellular lifespan extension. MicroRNAs (miRNAs) are endogenous small non-coding RNAs, which control gene expression in different tissues. In skeletal muscle, a range of miRNAs, named myomiRNAs, are involved in many physiological processes, such as growth, development, and maintenance of muscle mass and function. This review aims to present and to discuss some of the most relevant molecular mechanisms related to the pathophysiological effect of sarcopenia. Besides, we explored the role of nutrition as a possible way to counteract the loss of muscle mass and function associated with ageing, with special attention paid to nutrient-dependent miRNAs regulation. This review will provide important information to better understand sarcopenia and, thus, to facilitate research and therapeutic strategies to counteract the pathophysiological effect of ageing.
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作者：
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发表时间：
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