Novel experimental model for studying the spatiotemporal electrical signature of acute myocardial ischemia: a translational platform.
Novel experimental model for studying the spatiotemporal electrical signature of acute myocardial ischemia: a translational platform.
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DOI：
10.1088/1361-6579/ab64b9
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发表时间：
2020-02-05
影响因子：
3.2
通讯作者：
MacLeod RS
中科院分区：
文献类型：
--
作者：
Zenger B;Good WW;Bergquist JA;Burton BM;Tate JD;Berkenbile L;Sharma V;MacLeod RS
心肌缺血是最常见的心血管疾病之一，可能预示着许多严重且危及生命的疾病。尽管存在这些风险，目前用于缺血的心电图检测技术充其量是平庸的，报告的灵敏度和特异性分别为50-70%和70- 90%。为了提高这一性能，我们着手开发一种实验制剂，以诱导，检测和分析心肌缺血的生物电来源，并确定这些来源如何反映体表电位测量的变化。我们设计了具有三个重要特征的实验准备：（1）能够在心肌壁内、心脏表面和躯干表面上进行全面和同步的高分辨率电记录;（2）开发在时间和空间上可视化这些记录的电信号的技术;以及（3）通过调节血液的供应、灌注的需求或两者的组合来精确且可控地模拟心脏内的缺血性应激。为了实现这些目标，我们设计了综合系统，包括（1）定制电极阵列（2）信号采集和多路复用单元，（3）放置电记录和心肌缺血控制设备的手术技术，以及（4）基于图像的建模管道，以采集，处理和可视化结果。通过这种设置，我们能够同时连续捕获心脏内、心脏表面和体表的急性心肌缺血的电特征。这种新的实验制剂能够研究急性心肌缺血的复杂性和动态性，这将导致新的临床可转化的结果。
Myocardial ischemia is one of the most common cardiovascular pathologies and can indicate many severe and life threatening diseases. Despite these risks, current electrocardiographic detection techniques for ischemia are mediocre at best, with reported sensitivity and specificity ranging from 50–70% and 70–90%, respectively. To improve this performance, we set out to develop an experimental preparation to induce, detect, and analyze bioelectric sources of myocardial ischemia and determine how these sources reflect changes in body-surface potential measurements. We designed the experimental preparation with three important characteristics: (1) enable comprehensive and simultaneous high-resolution electrical recordings within the myocardial wall, on the heart surface, and on the torso surface; (2) develop techniques to visualize these recorded electrical signals in time and space; and (3) accurately and controllably simulate ischemic stress within the heart by modulating the supply of blood, the demand for perfusion, or a combination of both. To achieve these goals we designed comprehensive system that includes (1) custom electrode arrays (2) signal acquisition and multiplexing units, (3) a surgical technique to place electrical recording and myocardial ischemic control equipment, and (4) an image based modeling pipeline to acquire, process, and visualize the results. With this setup, we are uniquely able to capture simultaneously and continuously the electrical signatures of acute myocardial ischemia within the heart, on the heart surface, and on the body surface. This novel experimental preparation enables investigation of the complex and dynamic nature of acute myocardial ischemia that should lead new, clinically translatable results.
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影响因子：
37.8
作者：
KUBOTA, I;YAMAKI, M;TOMOIKE, H
通讯作者：
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