A chronological study of the bacterial pathogen changes in acute neonatal bacterial conjunctivitis in southern China.
A chronological study of the bacterial pathogen changes in acute neonatal bacterial conjunctivitis in southern China.
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DOI：
10.1186/s12886-017-0570-8
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发表时间：
2017-09-26
影响因子：
2
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Tang S;Li M;Chen H;Ping G;Zhang C;Wang S
本课题旨在对2002年至2016年中国南部地区新生儿急性细菌性结膜炎病原菌的变化进行回顾性研究。本研究结果可为新生儿急性细菌性结膜炎的药物选择提供指导。对485例临床诊断为急性细菌性新生儿结膜炎患儿的分泌物标本进行细菌培养。革兰氏染色和细菌培养检测病原菌。通过对2002年至2016年中国南部地区485例新生儿急性结膜炎病原菌的分析，结膜囊分泌物中革兰阳性菌的检出总体呈下降趋势，革兰阴性菌的检出呈上升趋势。细菌阳性样本中的革兰氏阳性菌从2002年的82.6%逐年下降到2016年的72.4%。相应地，革兰阴性杆菌比例从2002年的17.4%上升到2016年的27.6%。值得注意的是，尽管有总体趋势，但从2011年到2012年，革兰氏阳性细菌的检测显著增加，而革兰氏阴性细菌的检测却显著下降。革兰氏阳性菌中，条件致病菌的比例呈上升趋势(表皮葡萄球菌和腐生葡萄球菌上升~60%)，金黄色葡萄球菌下降(下降~30%)和溶血性链球菌下降(下降~20%)。主要革兰氏阴性菌为淋球菌。总体而言，近15年来，中国南部地区新生儿急性细菌性结膜炎的菌种格局发生了变化。本文对中国南部地区近年来新生儿急性细菌性结膜炎患者结膜囊分泌物中的致病菌进行了趋势分析。这些数据可以为新生儿细菌性结膜炎的治疗方案提供有用的信息。
The aim of the project is to retrospectively study the changes in bacterial pathogens in acute neonatal bacterial conjunctivitis from 2002 to 2016 in Southern China. The results may provide the guidance for drug choice for acute neonatal bacterial conjunctivitis. Secretion specimens for bacterial culture were taken from 485 cases with clinically diagnosed acute bacterial neonatal conjunctivitis. Bacterial pathogens were detected by Gram staining and subsequent bacterial culture. From the analysis of the bacterial pathogens in 485 cases of acute neonatal conjunctivitis patients from 2002 to 2016 in Southern China, there is an overall trend of decreasing detection of Gram-positive bacteria and increasing detection of Gram-negative bacteria from the conjunctival sac secretions. Gram-positive bacteria in the bacteria-positive samples dropped year by year from 82.6% in 2002 to 72.4% in 2016. Accordingly, the ratio of Gram-negative bacteria increased from 17.4% in 2002 to 27.6% in 2016. Of note, despite the overall trend, there was a significant increase in detection of Gram-positive bacteria and decrease in detection of Gram-negative bacteria from 2011 to 2012. Among the Gram-positive bacteria, there is a trend of increasing percentage of the opportunistic pathogens (an ~60% increase in Staphylococcus epidermidis and Staphylococcus saprophytic) and decreasing percentage of Staphylococcus aureus (~30% decrease) and hemolytic streptococcus (~20% decrease) in the last 15 years. The main Gram-negative bacterium is Neisseria gonorrhoeae. Overall, there is a change in the pattern of bacterial species in acute neonatal bacterial conjunctivitis in Southern China in the last 15 years. Our study provides a trend analysis of the bacterial pathogens in the conjunctival sac secretions of the acute neonatal bacterial conjunctivitis patients in Southern China in recent years. This data could provide useful information regarding the treatment options for neonatal bacterial conjunctivitis.
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影响因子：
4.1
作者：
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通讯作者：
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