Maternal stress in pregnancy: considerations for fetal development.

Maternal stress in pregnancy: considerations for fetal development.
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DOI:
10.1016/j.jadohealth.2012.04.008
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发表时间:
2012-08
影响因子:
7.6
通讯作者:
DiPietro, Janet A.
DiPietro, Janet A.
中科院分区:
医学2区
文献类型:
--
作者:
DiPietro, Janet A.

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目前有显着的兴趣在何种程度上产前暴露,包括产妇的心理因素,影响儿童的结果。检测产前产妇心理困扰与儿童发育结果之间关联的研究在因果关系的推断方面面临着许多解释性挑战。其中一些是常见的许多类型的产前暴露,必须依赖于观察设计。这些挑战包括产前和产后接触之间的相互关系,以及遗传因素等其他共同影响来源的潜在作用。其他人则更具体地研究这一领域。其中包括:母亲报告的孩子的结果和母亲的心理属性之间的混淆研究;在区分母亲的压力从更普遍的方面母亲的个性困难;和皮质醇和母亲的心理压力的措施之间缺乏关联。本文认为这些方法的问题,并提供了一个额外的方法,专注于胎儿的神经行为识别潜在的机制,可能介导产妇的心理功能和胎儿神经系统的发展之间的关联。
There is significant current interest in the degree to which prenatal exposures, including maternal psychological factors, influence child outcomes. Studies that detect an association between prenatal maternal psychological distress and child developmental outcomes are subject to a number of interpretative challenges in the inference of causality. Some of these are common to many types of prenatal exposures that must necessarily rely on observational designs. Such challenges include the correlation between prenatal and postnatal exposures and the potential role of other sources of shared influence, such as genetic factors. Others are more specific to this area of research. These include: confounding between maternal report of child outcomes and the maternal psychological attributes under study; difficulties in distinguishing maternal stress from more ubiquitous aspects of maternal personality; and the lack of association between cortisol and measures of maternal psychological stress. This article considers these methodological issues and offers an additional methodology focused on fetal neurobehavior for discerning potential mechanisms that may mediate associations between maternal psychological functioning and the developing fetal nervous system.
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