HCV communication within ego-centric networks of men and women who inject drugs.

HCV communication within ego-centric networks of men and women who inject drugs.
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DOI:
10.1016/j.drugalcdep.2021.109157
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发表时间:
2021-12-01
影响因子:
4.2
通讯作者:
Falade-Nwulia O
Falade-Nwulia O
中科院分区:
医学2区
文献类型:
--
作者:
Felsher M;Tobin KE;Sulkowski M;Latkin C;Falade-Nwulia O

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利用注射吸毒者(PWID)社会网络之间的人际交流可能是提高对丙型肝炎(HCV)护理的认识和获取的一种创新策略。然而,对于PWID患者之间的HCV传播模式以及这些模式是否因性别而异所知甚少。在马里兰州巴尔的摩的一项随机HCV治疗干预试验中,从HCV感染的PWID中收集的基线自我中心网络数据进行了分析。采用Logistic广义估计模型来确定HCV传播的预测因子。227例PWID患者中,平均年龄为43.8岁(SD=10.3),女性占28.2% (n=64),男性占71.8% (n=163)。女性参与者报告了516个二元关系,男性参与者报告了1139个二元关系。尽管在社会人口统计学、风险行为和网络构成方面存在显著的性别差异,但在HCV传播模式方面差异不大。男性和女性与目前正在接受药物治疗的改变者(AOR为1.7,95% CI为1.3-2.4)、与参与者共享药物制剂设备的改变者(AOR为3.0,95% CI为1.9-4.6)、与亲属相比是性伴侣的改变者(AOR为3.0,95% CI为1.9-4.9)以及与被调查者信任度增加的改变者(AOR为1.1,95% CI为1.11.2)和每日/每周互动(AOR为1.7,95% CI为1.3-2.1)的改变者的HCV交流几率均增加。PWID与有关丙型肝炎病毒披露和信息的可信改变者进行了接触,强调了网络干预在这一弱势群体中可能发挥的重要作用。
Leveraging interpersonal communication among social networks of people who inject drugs (PWID) may be an innovative strategy to increase awareness and access to hepatitis C (HCV) care. However, little is known about HCV communication patterns among PWID and if these patterns vary by gender. Egocentric network data collected at baseline from HCV-infected PWID enrolled in a randomized HCV treatment intervention trial in Baltimore, Maryland was analyzed. Logistic generalized estimating models were conducted to identify predictors of HCV communication. Among 227 PWID, the mean age was 43.8 (SD=10.3), 28.2% (n=64) were women and 71.8% (n=163) were men. Female participants reported 516 dyadic relationships and male participants 1139 dyadic relationships. While there were significant gender differences based on socio-demographics, risk behavior and network composition, there were few differences in HCV communication patterns. Both men and women had increased odds of HCV communication with alters who are currently enrolled in drug treatment (AOR 1.7, 95% CI: 1.3–2.4), alters with whom participants share drug preparation equipment (AOR 3.0, 95% CI: 1.9–4.6), alters who are sex partners compared to kin (AOR 3.0; 95% CI: 1.9–4.9) and alters with whom respondents have increased trust (AOR 1.1; 95% CI: 1.11.2) and daily/weekly interactions (AOR 1.7; 95% CI 1.3–2.1). PWID engaged with trusted alters about HCV disclosure and information, highlighting the important role network interventions could play in this vulnerable population.
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