The development of autism spectrum disorders: variability and causal complexity.

The development of autism spectrum disorders: variability and causal complexity.
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自闭症谱系障碍的发展:变异性和因果复杂性。

DOI:
10.1002/wcs.1426
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发表时间:
2017
期刊:
Wiley interdisciplinary reviews. Cognitive science
影响因子:
--
通讯作者:
Iverson,JanaM
Iverson,JanaM
中科院分区:
--
文献类型:
--
作者:
Wozniak,RobertH;Leezenbaum,NinaB;Northrup,JessieB;West,KelseyL;Iverson,JanaM

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自闭症谱系在行为和神经发育方面都是高度可变的。总的来说,造成这种变异的因素有四个:(1)遗传过程;(2)环境事件;(3)基因与环境的相互作用;(4)发育因素。考虑到相关过程的复杂性,似乎不太可能将自闭症谱系的非典型性归因于任何一种因果机制。相反,神经非典型性的发展反映了遗传和环境风险因素的相互作用。随着个体的成长,神经非典型性的变化,随之而来的行为变化,以及对这种行为的环境反应,可能会在一个正反馈循环中联系起来,从而放大与典型发展模式的偏差。电线学报,2017,(8):1426。doi: 10.1002 / wcs。本文分类如下:神经科学>临床神经科学>发展
The autism spectrum is highly variable, both behaviorally and neurodevelopmentally. Broadly speaking, four related factors contribute to this variability: (1) genetic processes, (2) environmental events, (3) gene × environment interactions, and (4) developmental factors. Given the complexity of the relevant processes, it appears unlikely that autism spectrum atypicalities can be attributed to any one causal mechanism. Rather, the development of neural atypicality reflects an interaction of genetic and environmental risk factors. As the individual grows, changes in neural atypicality, consequent variation in behavior, and environmental response to that behavior may become linked in a positive feedback loop that amplifies deviations from the typical developmental pattern.WIREs Cogn Sci2017, 8:e1426. doi: 10.1002/wcs.1426This article is categorized under:Neuroscience > Clinical NeuroscienceNeuroscience > Development
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