Association between Dietary Fatty Acid Patterns and Colorectal Cancer Risk: A Large-Scale Case-Control Study in China.
Association between Dietary Fatty Acid Patterns and Colorectal Cancer Risk: A Large-Scale Case-Control Study in China.
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饮食脂肪酸模式与大肠癌风险之间的关联：中国的一项大规模病例对照研究。
DOI：
10.3390/nu14204375
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发表时间：
2022-10-19
期刊：
影响因子：
5.9
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Tu K;Ma T;Zhou R;Xu L;Fang Y;Zhang C
膳食脂肪酸与结直肠癌（CRC）风险的关系仍存在争议。本研究的目的是检查中国人饮食来源的脂肪酸模式是否与CRC风险相关。在2010年7月至2021年5月期间，在这项病例对照研究中，共采访了2806名CRC患者和2806名频率匹配的对照。食物频率问卷被用来收集饮食摄入的信息。四种脂肪酸模式，确定使用因子分析。偶数长链脂肪酸模式与结直肠癌风险无统计学显著相关性（校正比值比（aOR），1.16; 95%置信区间（CI），0.97-1.39; ptrend = 0.129）。然而，中链和长链饱和脂肪酸（SFA）模式之间存在显著的负相关性（aOR，0.34; 95%CI，0.27-0.42），高度不饱和脂肪酸模式（aOR，0.73; 95%CI，0.60-0.88）、奇链脂肪酸模式（aOR，0.69; 95%CI，0.57-0.83）和CRC风险。观察到脂肪酸模式和性别之间的相互作用，高度不饱和脂肪酸模式和CRC风险之间的关联因子位点而异。总之，增加富含中链脂肪酸、高度不饱和脂肪酸和奇链脂肪酸的食物摄入量可能与降低CRC风险有关。
Associations of dietary fatty acids with the risk of colorectal cancer (CRC) remain controversial. The objective of this study was to examine whether dietary-derived fatty acid patterns were related to CRC risk among Chinese people. A total of 2806 CRC patients and 2806 frequency-matched controls were interviewed in this case-control study between July 2010 and May 2021. A food frequency questionnaire was used to gather information on dietary intake. Four fatty acid patterns were identified using factor analysis. The even-long-chain fatty acid pattern had no statistically significant association with CRC risk (adjusted Odds ratio (aOR), 1.16; 95% confidence interval (CI), 0.97–1.39; ptrend = 0.129). However, significant inverse associations were found between the medium-chain and long-chain saturated fatty acid (SFA) pattern (aOR, 0.34; 95%CI, 0.27–0.42), the highly unsaturated fatty acid pattern (aOR, 0.73; 95%CI, 0.60–0.88), the odd-chain fatty acid pattern (aOR, 0.69; 95%CI, 0.57–0.83), and CRC risk. The interaction between fatty acid patterns and sex was observed, and the association between the highly unsaturated fatty acid pattern and CRC risk differed by subsite. In conclusion, increasing the intakes of foods rich in medium-chain SFAs, highly unsaturated fatty acids, and odd-chain fatty acids may be related to a lower risk of CRC.
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影响因子：
7.1
作者：
Imamura, Fumiaki;Lemaitre, Rozenn N.;Mozaffarian, Dariush
通讯作者：
Mozaffarian, Dariush
影响因子：
6.4
作者：
Czene, K;Lichtenstein, P;Hemminki, K
通讯作者：
Hemminki, K
影响因子：
13.6
作者：
Hermelink, Rafael;Leitzmann, Michael F.;Markozannes, Georgios;Tsilidis, Kostas;Pukrop, Tobias;Berger, Felix;Baurecht, Hansjoerg;Jochem, Carmen
通讯作者：
Jochem, Carmen
DOI：
10.3390/molecules20022425
发表时间：
2015-01-30
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Jenkins B;West JA;Koulman A
通讯作者：
Koulman A
影响因子：
7.9
作者：
Butler LM;Yuan JM;Huang JY;Su J;Wang R;Koh WP;Ong CN
通讯作者：
Ong CN