Sedentary behavior and cancer-an umbrella review and meta-analysis.
Sedentary behavior and cancer-an umbrella review and meta-analysis.
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DOI：
10.1007/s10654-022-00873-6
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发表时间：
2022-05
影响因子：
13.6
通讯作者：
Jochem, Carmen
中科院分区：
文献类型：
--
作者：
Hermelink, Rafael;Leitzmann, Michael F.;Markozannes, Georgios;Tsilidis, Kostas;Pukrop, Tobias;Berger, Felix;Baurecht, Hansjoerg;Jochem, Carmen
一些系统性综述和荟萃分析总结了久坐行为（SB）与癌症之间的关联。然而，证据水平和偏倚风险的可能性仍不清楚。本综述总结了SB与癌症发病率和死亡率相关的当前数据，特别强调评估偏倚风险。我们在PubMed、Web of Science和科克伦数据库中检索了关于SB与癌症发病率和死亡率之间关系的系统综述和荟萃分析。我们还检索了尚未纳入现有荟萃分析的近期观察性研究。我们使用随机效应模型重新计算了癌症发病率和死亡率的总体风险估计。我们纳入了14项荟萃分析，涵盖了77项原始研究中的17个不同癌症部位。我们发现高SB水平会增加患卵巢癌、子宫内膜癌、结肠癌、乳腺癌、前列腺癌和直肠癌的风险，相对风险为1.29（95%置信区间（CI）= 1.08-1.56），1.29（95% CI = 1.16-1.45）、1.25（95% CI = 1.16-1.33）、1.08（95% CI = 1.04-1.11）、1.08（95% CI = 1.00-1.17）和1.07（95% CI = 1.01-1.12）。此外，我们发现癌症死亡率增加1.18（95% CI = 1.09-1.26）。SB和特定癌症部位之间的大多数关联都得到了“暗示性”证据的支持。高水平的SB与几种癌症的风险增加和癌症死亡风险增加有关。在线版本包含补充材料，可通过10.1007/s10654-022-00873-6获得。
Several systematic reviews and meta-analyses have summarized the association between sedentary behavior (SB) and cancer. However, the level of evidence and the potential for risk of bias remains unclear. This umbrella review summarized the current data on SB in relation to cancer incidence and mortality, with a particular emphasis on assessing the risk of bias. We searched PubMed, Web of Science and Cochrane Database for systematic reviews and meta-analyses on the association between SB and cancer incidence and mortality. We also searched for recent observational studies not yet included in existing meta-analyses. We re-calculated summary risk estimates for cancer incidence and mortality using random effects models. We included 14 meta-analyses covering 17 different cancer sites from 77 original studies. We found that high SB levels increase the risk for developing ovarian, endometrial, colon, breast, prostate, and rectal cancers, with relative risks of 1.29 (95% confidence interval (CI) = 1.08–1.56), 1.29 (95% CI = 1.16–1.45), 1.25 (95% CI = 1.16–1.33), 1.08 (95% CI = 1.04–1.11), 1.08 (95% CI = 1.00–1.17), and 1.07 (95% CI = 1.01–1.12), respectively. Also, we found an increased risk of cancer mortality of 1.18 (95% CI = 1.09–1.26). Most associations between SB and specific cancer sites were supported by a “suggestive” level of evidence. High levels of SB are associated with increased risk of several types of cancer and increased cancer mortality risk. The online version contains supplementary material available at 10.1007/s10654-022-00873-6.
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DOI：
10.1097/cej.0000000000000351
发表时间：
2018-07
期刊：
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
影响因子：
--
作者：
Gorczyca AM;Eaton CB;LaMonte MJ;Garcia DO;Johnston JD;He K;Bidulescu A;Goodman D;Groessl E;Lane D;Stefanick ML;Newcomb P;Mouton C;Chomistek AK
通讯作者：
Chomistek AK
影响因子：
45.3
作者：
Campbell, Peter T.;Patel, Alpa V.;Gapstur, Susan M.
通讯作者：
Gapstur, Susan M.
影响因子：
39.3
作者：
Healy, Genevieve N.;Matthews, Charles E.;Owen, Neville
通讯作者：
Owen, Neville
影响因子：
2
作者：
Harbord, Roger M.;Egger, Matthias;Sterne, Jonathan A. C.
通讯作者：
Sterne, Jonathan A. C.
DOI：
10.1007/s10552-015-0645-x
发表时间：
2015-10
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Cao Y;Meyerhardt JA;Chan AT;Wu K;Fuchs CS;Giovannucci EL
通讯作者：
Giovannucci EL