Differentially expressed microRNAs in postpartum breast cancer in Hispanic women.
Differentially expressed microRNAs in postpartum breast cancer in Hispanic women.
复制标题
在西班牙裔女性的产后乳腺癌中差异表达的microRNA。
DOI：
10.1371/journal.pone.0124340
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Martinez ME
中科院分区：
文献类型：
--
作者：
Muñoz-Rodríguez JL;Vrba L;Futscher BW;Hu C;Komenaka IK;Meza-Montenegro MM;Gutierrez-Millan LE;Daneri-Navarro A;Thompson PA;Martinez ME
The risk of breast cancer transiently increases immediately following pregnancy; peaking between 3-7 years. The biology that underlies this risk window and the effect on the natural history of the disease is unknown. MicroRNAs (miRNAs) are small non-coding RNAs that have been shown to be dysregulated in breast cancer. We conducted miRNA profiling of 56 tumors from a case series of multiparous Hispanic women and assessed the pattern of expression by time since last full-term pregnancy. A data-driven splitting analysis on the pattern of 355 miRNAs separated the case series into two groups: a) an early group representing women diagnosed with breast cancer ≤ 5.2 years postpartum (n = 12), and b) a late group representing women diagnosed with breast cancer ≥ 5.3 years postpartum (n = 44). We identified 15 miRNAs with significant differential expression between the early and late postpartum groups; 60% of these miRNAs are encoded on the X chromosome. Ten miRNAs had a two-fold or higher difference in expression with miR-138, miR-660, miR-31, miR-135b, miR-17, miR-454, and miR-934 overexpressed in the early versus the late group; while miR-892a, miR-199a-5p, and miR-542-5p were underexpressed in the early versus the late postpartum group. The DNA methylation of three out of five tested miRNAs (miR-31, miR-135b, and miR-138) was lower in the early versus late postpartum group, and negatively correlated with miRNA expression. Here we show that miRNAs are differentially expressed and differentially methylated between tumors of the early versus late postpartum, suggesting that potential differences in epigenetic dysfunction may be operative in postpartum breast cancers.
登录
查看更多内容
产后乳房的相互作用揭示了组织造型介导的分泌小叶的消退。
DOI：
10.1186/bcr3633
发表时间：
2014-03-28
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Jindal S;Gao D;Bell P;Albrektsen G;Edgerton SM;Ambrosone CB;Thor AD;Borges VF;Schedin P
通讯作者：
Schedin P
影响因子：
5
作者：
Chie, WC;Hsieh, CC;MacMahon, B
通讯作者：
MacMahon, B
影响因子：
11.2
作者：
Kozaki, Ken-ichi;Imoto, Issei;Inazawa, Johji
通讯作者：
Inazawa, Johji
Mirbase：MicroRNA基因组学的工具。
影响因子：
14.9
作者：
Griffiths-Jones, Sam;Saini, Harpreet Kaur;van Dongen, Stijn;Enright, Anton J.
通讯作者：
Enright, Anton J.
影响因子：
14.9
作者：
Griffiths-Jones S;Grocock RJ;van Dongen S;Bateman A;Enright AJ
通讯作者：
Enright AJ