Lactation intensity and fasting plasma lipids, lipoproteins, non-esterified free fatty acids, leptin and adiponectin in postpartum women with recent gestational diabetes mellitus: the SWIFT cohort.
Lactation intensity and fasting plasma lipids, lipoproteins, non-esterified free fatty acids, leptin and adiponectin in postpartum women with recent gestational diabetes mellitus: the SWIFT cohort.
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DOI：
10.1016/j.metabol.2014.04.006
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发表时间：
2014-07
影响因子：
9.8
通讯作者：
Dewey, Kathryn G.
中科院分区：
文献类型：
--
作者：
Gunderson, Erica P.;Kim, Catherine;Quesenberry, Charles P.;Marcovina, Santica;Walton, David;Azevedo, Robert A.;Fox, Gary;Elmasian, Cathie;Young, Stephen;Salvador, Nora;Lum, Michael;Crites, Yvonne;Lo, Joan C.;Ning, Xian;Dewey, Kathryn G.
哺乳可能影响妊娠糖尿病（GDM）后向2型糖尿病的进展。然而，尚未检查与葡萄糖不耐受进展相关的生物标志物与既往患有GDM的产后妇女的哺乳强度的关系。本研究调查是否更高的泌乳强度与更有利的血脂，脂蛋白和脂肪因子GDM妊娠后独立的肥胖，社会人口统计学和胰岛素抵抗。妇女、婴儿喂养和2型糖尿病研究（SWIFT）是一项前瞻性队列研究，招募了1,035名在2008-2011年分娩活产后通过3小时100 g口服葡萄糖耐量试验（OGTT）诊断为GDM的妇女。研究人员进行2小时75克OGTT，并在产后6-9周（基线）评估泌乳强度、人体测量、生活方式行为和社会人口统计学。我们从1,007名基线时无糖尿病的SWIFT参与者的产后6-9周获得的储存样本中检测了空腹血脂、脂蛋白、非酯化游离脂肪酸、瘦素和脂联素。使用多变量线性回归模型比较泌乳强度组之间的平均生物标志物浓度。增加泌乳强度与完全校正的平均生物标志物呈分级单调相关：高密度脂蛋白胆固醇（HDL-胆固醇）升高5-8%，空腹甘油三酯降低20-28%，瘦素降低15-21%（所有趋势P值<0.01），脂联素降低6%，但仅在校正胰岛素抵抗后（趋势P值=0.04）。在GDM分娩后，较高的泌乳强度与更有利的2型糖尿病生物标志物相关，除了较低的血浆脂联素。需要长期随访研究来评估哺乳的这些影响是否持续，以预测葡萄糖耐受不良的进展。
Lactation may influence future progression to type 2 diabetes after gestational diabetes mellitus (GDM). However, biomarkers associated with progression to glucose intolerance have not been examined in relation to lactation intensity among postpartum women with previous GDM. This study investigates whether higher lactation intensity is related to more favorable blood lipids, lipoproteins and adipokines after GDM pregnancy independent of obesity, socio-demographics and insulin resistance. The Study of Women, Infant Feeding, and Type 2 Diabetes (SWIFT) is a prospective cohort study that recruited 1,035 women diagnosed with GDM by the 3-hour 100 g oral glucose tolerance tests (OGTTs) after delivery of a live birth in 2008–2011. Research staff conducted 2-hour 75 gram OGTTs, and assessed lactation intensity, anthropometry, lifestyle behaviors and socio-demographics at 6–9 weeks postpartum (baseline). We assayed fasting plasma lipids, lipoproteins, non-esterified free fatty acids, leptin and adiponectin from stored samples obtained at 6–9 weeks postpartum for in 1,007 of the SWIFT participants who were free of diabetes at baseline. Mean biomarker concentrations were compared among lactation intensity groups using multivariable linear regression models. Increasing lactation intensity showed graded monotonic associations with fully adjusted mean biomarkers: 5–8% higher high-density lipoprotein cholesterol (HDL-cholesterol), 20–28% lower fasting triglycerides, 15–21% lower leptin (all trend P-values<0.01), and with 6% lower adiponectin, but only after adjustment for insulin resistance (trend P-value=0.04). Higher lactation intensity was associated with more favorable biomarkers for type 2 diabetes, except for lower plasma adiponectin, after GDM delivery. Long-term follow-up studies are needed to assess whether these effects of lactation persist to predict progression to glucose intolerance.
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DOI：
10.1038/oby.2010.189
发表时间：
2011-02
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Hivert MF;Sun Q;Shrader P;Mantzoros CS;Meigs JB;Hu FB
通讯作者：
Hu FB
影响因子：
5.8
作者：
Matsubara, M;Katayose, S;Maruoka, S
通讯作者：
Maruoka, S
影响因子：
7.7
作者：
Gunderson EP;Jacobs DR Jr;Chiang V;Lewis CE;Feng J;Quesenberry CP Jr;Sidney S
通讯作者：
Sidney S
影响因子：
7.7
作者：
Hanley, AJG;Williams, K;Haffner, SM
通讯作者：
Haffner, SM
影响因子：
7.2
作者：
Gunderson EP;Crites Y;Chiang V;Walton D;Azevedo RA;Fox G;Elmasian C;Young S;Salvador N;Lum M;Hedderson MM;Quesenberry CP;Lo JC;Ferrara A;Sternfeld B
通讯作者：
Sternfeld B